Astrazeneca Ab

Pulmagen Therapeutics (synergy) Limited

Rhonan Lee Ford

Barry John Teobald

Antonio Mete

Andrew Mather

Paul Andrew Willis

Austen Pimm

Richard Evans

Ian Millichip

Barrie Martin

Moya Caffrey

Richard James Bull

Toby Thompson

Christine Eyssade

The invention provides named compounds of formula (I), wherein R4 is a N-substituted quinuclidine (I) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed. 

Quinuclidine derivatives as muscarinic M3 receptor antagonists

The invention provides compounds of formula (I) wherein Ris a group of formula (II) or (IIIa) or (IIIb) and R, R, R, R, a, b and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions, their use in therapy and intermediates of use in their preparation (I), (II), (IIIa), (IIIb). 

Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists

The present invention provides compounds of formula (I) in which y, m, n, R, Rand Q are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.

Substituted 1-cyanoethylheterocyclylcarboxamide compounds

The invention provides compounds of formula (IA), processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. 

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The invention provides compounds of formula in which m, n, R, R, R, R, and R, have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.

Adamantane derivatives, processes for their preparation and pharmaceutical composition containing them

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Loughborough, United Kingdom

Rhonan Lee Ford