Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Chinoin Gyogyszer Es Vegyeszeti

Eszakmagyarorszagi Vegyimuvek

Biogal Gyogyszergyar

Chinoin Pharmaceutical and Chemical Works Ltd.

Rezso Bognar

Sandor Makleit

Jozsef Knoll

Zoltan Meszaros

Agoston David

Zsuzsanna Furst

Gyula Valovics

Istvan Hermecz

Attila Mandi

Gabor Nagy

Peter Szentmiklosi

Sandor J Nagy

Istvan Toth

Karoly Balogh

Janos Balint

Sandor Jancso

Laszlo Litkei

Karoly Lapis

Istvan Kovacs

Ferenc Mogyorodi

Bela Szende

Tibor Bodi

Istvan Gyoker

Geza Horvath

Ildiko Mihok Nee Borbely

Geza Kiss

Sandor Berenyi

Gyorgy Toth

Attila Zoltai

Sandor Elek

Terez Mile

Eniko Koppany

Gyorgy Litkei

Miklos Rakosi

Zoltan Dinya

Zoltan Gyorgydeak

Judit Krusper Nee Ham

Attila Jakab

Ferenc Pusztai

Terezia Mile

Andras Jenei

Laszlo Szlavik

Mariann Fekete Nee Huszka

Laszlo Szavik

The invention relates to novel thiazolidine-4(S)-carboxylic acid derivatives of the general formula (I) ##STR1## wherein R.sup.1 stands for an optionally substituted furyl, pyrrolyl, thienyl, benzofuryl, benzopyrrolyl, benzothienyl, phenyl, pyridyl, quinolinyl, isoquinolinyl or indanyl group or a C.sub.1-4 alkyl or C.sub.2-4 alkenyl group optionally substituted by a hydroxyl, carboxyl or halogen fenoxy group,

Thiazolidinecarboxylic acid derivatives and treatment of liver diseases

The invention relates to a novel process for preparing chloroacetanilides of the formula ##STR1## wherein: R.sub.1 and R.sub.2 represent independently from each other a hydrogen atom or a C.sub.1-8 alkyl or C.sub.1-8 alkoxy group; and

Process for the preparation of substituted chloroacetanilides

Azidoethylmorphine, a new 7,8-dihydroisomorphine derivative, has excellent antitussive effects without respiration depression.

7,8-Dihydroisomorphine derivative, namely azidoethylmorphine

A pharmaceutical composition with synergistic analgesic effect which comprises an effective amount of 6-desoxy-6-azido-14-hydroxy-7,8-dihydro morphine or codeine or an analgesically effective salt thereof and an effective amount of a compound ##STR1## wherein R.sup.1 and R.sup.2 are lower alkyl and R.sup.3 is hydrogen or lower alkyl, and the dotted lines represent hydrogenated or unsaturated bonds or an analgesically effective salt or quaternary compound thereof.

Pharmaceutical composition having synergistic analgesic activity and

Pharmaceutical compositions of synergistic analgesic activity are provided which comprise an azido compound of the following formula: ##STR1## or a salt thereof wherein R is hydrogen, methyl, ethyl, acetyl or morpholino-methyl and a compound of the formula: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 are hydrogen or lower alkyl and the dotted lines represent hydrogenated bonds or olefinic bonds and pharmaceutically acceptable salts and quaternary salts thereof, in admixture with suitable inert solid or liquid carriers or dilutents.

Pharmaceutical composition having synergistic analgesic activity

A pharmaceutical composition having synergistic analgesic effect which includes an azido compound of the formula: ##SPC1## namely an azido morphine or an azido codeine, and at least one compound of the formula: ##SPC2## The synergistic composition has been found to have less narcotic side effects than morphine and equal or better analgesic properties.

An analgesic substitute for morphine comprising the synergistic combination of azidomorphine or azidocodeine with a pyrimidazolium.

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Debrecen, Hungary

Rezso Bognar