The Schepens Eye Research Institute, Inc.

Massachusetts Eye and Ear Infirmary

The Brigham and Women's Hospital, Inc.

Johnson and Johnson Vision Care, Inc.

Schepens Eye Research

Reza Dana

Charles Nicholas Serhan

Frank Molock

Sunil Chauhan

Haobing Wang

Francisco L Amparo Pulido

Pedram Hamrah

Bernardo Cavalcanti

Andrea Cruzat

Mohammad Dastjerdi

Ali Khademhosseini

Nasim Annabi

Ahmad Kheirkhah

Yihe Chen

Daniel Saban

Yiping Jin

Ula V Jurkunas

Francisco L Pulido

Debra Schaumberg

Lenora Copper

Shiv Mahadevan

Kathy Osborn Lorenz

Saadia Rashid

Mohammed Dastjerdi

The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.

Grading corneal fluorescein staining

This application discloses ophthalmic formulations and methods for treating and preventing corneal haze and scarring with an hepatocyte growth factor (HGF) agent.

Compositions and methods for prevention and treatment of corneal haze and scarring

Methods and compositions for reducing the activity or number of memory Th17 cells in ocular tissue, and for treatment and/or prevention of ocular immunoinflammatory diseases are described.

Therapeutics for ocular immunoinflammatory diseases

The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.

Calculating conjunctival redness

The invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-17 and methods for using this composition to treat IL-17-mediated ocular inflammatory disorders. The invention also discloses devices for delivering this composition to the eye.

Therapeutic compositions for treatment of ocular inflammatory disorders

The present invention provides compositions and methods for repair and reconstruction of defects and injuries to the cornea.

Bioadhesive for corneal repair

Described herein are materials and methods for treating dry eye disease in a subject.

Therapeutic compositions for the treatment of dry eye disease

Described herein are materials and methods of treating dry eye disease in a subject.

The invention provides methods and compositions for minimizing, preventing, or treating damage to corneal nerves by administering to a subject with such damage or at risk of exposure to such damage a composition which blocks an activity of an IL-1 cytokine and/or an IL-17 cytokine.

Methods for reducing corneal nerves damage, corneal lymphangiogenesis or immunity to corneal antigens in dry-eye associated ocular surface diseases by IL-1Ra

The present invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-1 and methods for using this composition to treat inflammatory disease of ocular and adnexal tissues by topical administration. The present invention also discloses devices for delivering this composition to target tissues.

Growing community of inventors

Newton, MA, United States of America

Reza Dana