Alexza Pharmaceuticals, Inc.

Bausch + Lomb Ireland Limited

Other

Zoll Circulation, Incorporated

Njoy, Inc.

Novartis Ag

Pari Pharma Gmbh

Kedalion Therapeutics, Inc.

Daniel D. Rogers

Daniel J. Myers

Jeffrey a. Mckinney

Martin J. Wensley

Daniel Mufson

Ron L. Hale

Soonho Song

Reynaldo J Quintana

Ron L Hale

Daniel J Myers

Joshua D Rabinowitz

Martin J Wensley

Peter Lloyd

Daniel V Palanker

Curtis Peter Tom

Craig C Hodges

Yehuda Ivri

Dennis Solas

Jeffrey Alan McKinney

Daniel David Rogers

Mark S Blumenkranz

Pravin L Soni

Alejandro C Zaffaroni

Gregory Walter Hall

Ramesh Damani

Paul Quentin Escudero

Charles E Swinehart

Krishnamohan Sharma

Robert D Rosenthal

Stefan Biel

Thomas Gallem

Bob H Katz

Mark Duncan Brinkerhoff

Stephen Pham

Uwe Hetzer

Timothy R Dalbec

Amy Tsai Lu

James O Jensen

Vladimir Rappoport

Lynn N Paynter

Robert Mastromattei

Stephen D Cross

Mark Blumenkranz

Khe Kubel

Tom Geraty

Casey Dougan

Ehud Ivri

Kirshnamohan Sharma

Daniel D Rogers

Peter M Lloyd

Jeffrey A Mckinney

Stephen Cross

Dennis W Solas

The temperature of a vaporizing device, e.g., the temperature of a heating element of the vaporizing device, may be controlled according to various aspects of the present disclosure. The vaporizing device may comprise a heating element, a power source, at least one sensor in electronic communication with the heating element and the power source, and a processor configured to control the temperature of the heating element. The method of controlling the temperature may comprise receiving a resistance measurement of the heating element from the at least one sensor, determining the temperature of the heating element based on the resistance measurement, and adjusting the amount of power supplied to the heating element based on the determined temperature of the heating element.

Heating control for vaporizing device

The efficacy of a dosing regimen can be altered, and preferably improved, by fractionating the doses. Here fractionating the doses can be regarded as taking a single conventional dose and splitting that dose into two or more dose-fractions delivered at relatively short time intervals, where the dose-fractions add up to the same total dose as the conventional dose. In cases where dose fractionation increases the therapeutic effect, this can result in a greater therapeutic effect from a smaller total dose when the doses are fractionated. This effect has been demonstrated in an ophthalmic application, but is expected to be more generally applicable.

Fractionated topical ocular drug delivery methods and devices for use in the same

Multi-dose ocular fluid delivery devices are provided. Aspects of the fluid delivery devices include a fluid package and an actuator. The fluid package includes a reservoir of an ophthalmic formulation, an aperture and a valve member for sealing the aperture when fluid is not being ejected therethrough. The actuator operates the valve member so as to at least reduce, if not prevent, ingress of outside materials or contaminants into the reservoir. Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.

Multi-dose ocular fluid delivery system

Methods of administering a liquid formulation of an ophthalmic agent to a topical ocular location of an eye are provided. Aspects of the methods include delivering to the topical ocular location a dose of the liquid formulation that can be wholly accommodated by the tear film of the eye. Devices and kits for practicing the methods are also provided. The methods, compositions and kits find use in a variety of applications, including therapeutic, diagnostic and cosmetic applications. Further aspects include wireless communication between a handheld dispenser of the ophthalmic agent and external devices(s) to provide various functions.

Topical ocular delivery of fluids with controlled mass dosing and wireless communication

Aspects of the invention include a device for fluid delivery to the ocular surface having a self-alignment system. The fluid delivery device includes a fluid package having a reservoir and one or more apertures, an actuator component configured to eject fluid from the reservoir through the one or more apertures and an image-based self-alignment system configured to align fluid ejected through the one or more apertures with a target location on the eye of a user. Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.

Fluid delivery alignment system

A device for delivery of a precise amount of pharmaceutical fluid to the eye is provided. The device includes an ampoule for storing a liquid and an aperture through which the liquid is discharged. The device further includes a vibrating membrane that includes a needle which protrudes from the membrane and extends to the aperture to form a needle valve. The needle valve provides hermetic closure of the aperture to enable preservative-free storage of the pharmaceutical fluid in the device. The system further includes an electromagnetic transducer to shift the membrane back and forth in order to discharge liquid through the nozzle. Finally, the system further includes a vent to permit air to enter the ampoule as fluid is ejected from the ampoule. Preferably this vent includes a filter to prevent ingress of microbes or other contaminants to the ampoule.

Vented multi-dose ocular fluid delivery system

Multi-dose ocular fluid delivery devices are provided. Aspects of the fluid delivery devices include a fluid package and an actuator. The fluid package includes a reservoir of an ophthalmic formulation, an aperture and a valve member for sealing the aperture when fluid is not being ejected therethrough. The actuator is configured to operate the valve member so as to at least reduce, if not prevent, ingress of outside materials or contaminants into the reservoir, such that the ophthalmic formulation present in the reservoir does not require a preservative (e.g., where a preservative-free ophthalmic formulation is present in the reservoir). Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.

Aspects of the instant disclosure relate to electronic cigarettes with an active delivery system for transporting a liquid solution from a tank to an atomizer; and more particularly to oscillating diaphragm pumps that facilitate flow of the liquid solution from the tank and onto a heating coil of an atomizer for vaporization.

Electronic cigarette fluid pump

An opening element for opening an ampoule in an aerosol generation device includes a first member which has a conduit extending therethrough for guiding a fluid contained in the ampoule through the first member and a second member which is arranged at least partly inside or on the conduit. Further, an aerosol generation device includes such an opening element.

Opening element for opening an ampoule in an aerosol generation device and aerosol generation device comprising the opening element

Devices and methods for attaching a belt cartridge to a belt drive platform. A clip attached to the belt is inserted into a slot in the drive spool of the belt drive platform. The cover plate of the belt cartridge fits into a channel beam in the housing of the belt drive platform, thereby securing the cartridge to the housing. Belt guards, for protecting the cartridge, belt drive platform, patient and rescuer, are rotatably attached to the cover plate and are secured around spindles disposed on the sides of the housing.

Methods and devices for attaching a belt cartridge to a chest compression device

The present application relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition of a drug to form a vapor, wherein the coated composition is in the form of a film less than 10&#x3bc; thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method involves: (a) heating a substrate coated with a composition of a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

Method of forming an aerosol for inhalation delivery

Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.

Self-contained heating unit and drug-supply unit employing same

Growing community of inventors

Redwood City, CA, United States of America

Reynaldo J Quintana