Merck Sharp + Dohme Corp.

Reynalda DeJesus

Haifeng Tang

William K Hagmann

Alexander Pasternak

Fa-Xiang Ding

Guoqing Li

Li Xiao

Jing Su

Shuzhi Dong

Haiqun Tang

Weidong Pan

Dexi Yang

Mihir Mandal

Shu-Wei Yang

Barbara A Pio

Jinlong Jiang

Xin Gu

Clare London

Zhiqiang Zhao

Jacqueline D Hicks

Jianping Pan

Yuhua Huang

Katherine Young

Hong Dong Chu

Matthew Lombardo

Dipshikha Biswas

Nardos H Teumelsan

David N Hunter

Alex Pasternak

The present invention relates to compounds of formula I that are metallo-&#x3b2;-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with &#x3b2;-lactam antibiotics for overcoming resistance. 

Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors

The present invention relates to compounds of formula (I) that are metallo-&#x3b2;-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with &#x3b2;-lactam antibiotics for overcoming resistance. 

Metallo-beta-lactamase inhibitors

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

Inhibitors of the renal outer medullary potassium channel

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East Brunswick, NJ, United States of America

Reynalda DeJesus