Institut De Recherche Pour Le Developpement

Centre National De La Recherche Scientifique

Universite Nationale D'asuncion

Institut Francais De Recherche Scientifique Pour Le Developpment En

Reynald Hocquemiller

Alain Fournet

Bruno Figadere

Pascal Richomme

Xavier Franck

Mohamed Fakhfakh

Eric Prina

Jean Bruneton

Maria Elena Ferreira

Victoria Munoz

Francedillaois Roblot

Antonieta Rojas De Arias

Alcira Angelo Barrios

Jean Charles Gantier

Erwan Poupon

Maria-Elena Ferreira

A method of treating trypanosomiasis in a mammal, which entails administering to a mammal in need thereof an effective amount of medicinal producting comprising a plant extract comprising one or more compounds of formula (I).

Use of canthin-6-one, plant extracts containing same and derivatives thereof in the treatment of trypanosomiases

The invention relates to the use of quinolines having general formula (I), wherein Rdenotes H; alkyl C-C; alkenyl or alkynyl C-C; &#x2014;CHO; heteroaryl; alkyl C-Cor alkenyl or alkynyl C-Ccomprising at least one substituent selected from among O, halogen, &#x2014;OH, &#x2014;CHO, &#x2014;COOH, aryloxycarbonyl, alkyloxycarbonyl C-C, alkenyloxycarbonyl C-C, nitrile, aryl, heteroaryl, arylsulphone, alkylsulphone C-C, thioalkyl or aminoalkyl C-C; alkenyl C-Cbearing at least one substituent selected from among NH, aleoxy C-C, phenoxy, cycloakyl C-Cor heteroaryloxy, alkenyl or alkynyl C-Ccomprising at least one trialkylsilyl C-C; R, in position 3, 6 or 8, denotes H; halogen; &#x2014;OH; &#x2014;CHO; &#x2014;COOH; alkyl or aleoxy C-C; &#x2014;NH2; alkenyl C-C; or alkynyl C-C; Rand Rdo not both denote H. The invention is used for the preparation of a medicine to treat protozoan and retrovirus co-infections 

Substituted quinolines for the treatment of protozoa and retrovirus co-infections

2-substituted quinolines for the treatment of leishmaniasis

Growing community of inventors

Limours, France

Reynald Hocquemiller