Trellis Bioscience, Inc.

Telik, Inc.

Gryphon Therapeutics, Inc.

Micrologix Biotech Inc.

Reyna J Simon

Lawrence M Kauvar

Lauren Opremcak Bakaletz

Steven David Goodman

Angeles Estelles

Stefan Ryser

Stephen B H Kent

Louise Robinson

Steven R Schow

Natalia Aurrecoechea

Kevin T Weber

Lynne Canne

David J Loury

Songyuan Shi

Michael M Wick

Conway C Chang

Brian T Peterson

Robert R Webb

Michael A Siani

Wenli Ma

Paul Beroza

Andrew B Kelson

Jill Wilken

David R Allen

Robert W Macsata

Komath V Damodaran

Christopher J Baldwin

Binh T Dang

Truong Vu

Anthony J Sanchez

Nicholas M Santiago

Karen Y Pontius

Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

Binding moieties for biofilm remediation

Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and their salts are kinase inhibitors, useful in the treatment of cancer.

2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors

Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.

Sulfonylethyl phosphorodiamidates

Tripeptide and tetrapeptide thioethers, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.

Tripeptide and tetrapeptide thioethers

The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments using chemoselective and mild ligation chemistries in aqueous solution. Also provided are methods of monitoring solid phase sequential ligation reactions using MALDI or electrospray ionization mass spectrometry of reaction products.

Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution

Novel proteins and protein libraries are disclosed. The proteins possess one or more functional protein modules from different parent protein molecules. The proteins and protein libraries are exemplified by the preparation of cross-over chemokines that contain various combinations of peptide segments derived from RANTES, SDS-1 and vMIP-I and to vMIP-II. The proteins and libraries are extremely pure and can be provided in non-limiting high yields suitable for diagnostic and high-throughput screening assays.

Modular protein libraries and methods of preparation

The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit antifungal activity and are more water-soluble than conventional polyene antibiotics, such as amphotericin B and amphotericin B methyl ester.

Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof

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Los Gatos, CA, United States of America

Reyna J Simon