Methylgene, Inc.

Other

Methylgere, Inc.

Rex Pratt

Jeffrey M Besterman

Jubrail Rahil

The invention provides novel &#x3b2;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &#x3b2;-lactamase inhibitors presently available, and which do not possess a &#x3b2;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &#x3b2;-lactamase inhibitors and as antibiotics.

Acyl phosphonate inhibitors of &#x3b2;-lactamases

The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.

&bgr;-lactamase and DD-peptidase inhibitors

The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess a &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.

Acyl phosphonate inhibitors of &bgr;-lactamases

6.beta.-Bromo penicillanic acid is a novel compound which is an antibacterial agent as well as a potent .beta.-lactamase inhibitor.

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Portland, CT, United States of America

Rex Pratt