Warner-Lambert Company

Oclassen Pharmaceuticals, Inc.

Rex A Jennings

James R Zeller

Ronald E Seamans

Don R Johnson

Jay F Stearns

Kikuko Harasawa

Robert Wade

Christopher A Briggs

Shinsuke Nakagawa

Kazuo Minohara

Shigeru Ichikawa

Crystalline [R-

Novel cyanocycloalkylacetic acids and esters as well as salts thereof and in particular 1-cyanocyclohexaneacetic acid and ethyl 1-cyanocyclohexaneacetate are described which are useful as intermediates in a process for the preparation of cyclic amino acids.

Cyanocycloalkylacetic acid and ester intermediates for preparing cyclic

An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.

Process for cyclic amino acid anticonvulsant compounds

An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.

Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and

Podophyllotoxin is recovered from podophyllum resin with improved efficiency by adsorbing impurities out of a solution using a solid adsorbent, preferably alumina. This improvement finds application in an overall process for purifying podophyllotoxin from podophyllum resin in which the podophyllotoxin is first crystallized from the podophyllum resin, the crystals so formed are dissolved and subjected to the solid adsorbent treatment, crystals are then recovered and optionally recrystallized and dried to give the desired product.

Podophyllotoxin purification process

Growing community of inventors

Holland, MI, United States of America

Rex A Jennings