Technion Research & Development Foundation Ltd

Tel Aviv University

Rambam Med-Tech Ltd.

Other

Walter Gabriel Wasser

Revital Shemer

Karl L Skorecki

Shay Tzur

Saharon Rosset

Doron M Behar

Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity onas compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on theunder identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequilibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.

Methods and kits for determining predisposition to develop kidney diseases

Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity onas compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on theunder identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequlibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.

Growing community of inventors

Haifa, Israel

Revital Shemer