Uvic Industry Partnerships Inc.

Other

Biomark Technologies, Inc.

Reuven Gordon

Thomas E Darcie

Brian K Cheng

Rashid Bux

Fraser Hof

David Sinton

Skyler Wheaton

Aftab Ahmed

Yuanjie Pang

Afshin Jooshesh

Ryan M Gelfand

Carlos Escobedo

Alexandre Brolo

Barmak Heshmat

Bram Ramjiawan

Brian Cheng

Fraser Alan Hof

Disclosed are systems and methods for improving applications involving the generation and detection of electromagnetic radiation at terahertz (THz) frequencies. Embodiments of the systems and methods include the fabrication and use of plasmonic devices that enhance light-matter interaction at the nanometer scale by extreme focusing with nanostructured metals. This plasmonic enhancement is used to produce high efficiency THz photoconductive switches that combine the benefits of low-temperature grown GaAs while using mature 1.55 &#x3bc;m femtosecond lasers operating with photon energy below the GaAs band-gap.

Plasmon-enhanced below bandgap photoconductive terahertz generation and detection

Optically trapped specimens (typically nanoparticles having diameters between 1 and 50 nm) are excited with an optical beam so as to induce vibrations in the specimens. A trapping optical beam and the excitation optical beam can produce vibrations based on a difference frequency based on the trapping optical beam and the excitation optical beam. Scattered optical radiation as a function of modulation frequency can be recorded and used to identify or characterize the specimen.

Laser tweezer system for measuring acoustic vibrations of nanoparticles

A method for quantifying acetylamantadine in a urine sample comprises eluting acetylamantadine from the urine sample using solid phase extraction and quantifying the acetylamantadine eluted from the urine sample using Raman spectroscopy.

Detection and quantification of acetylamantadine in urine samples

Molecules or particle having a hydrodynamic radius as small as 3.5 nm can be trapped using a double-nanohole structure defined in a metal film or other metallic layer. Application of a suitable optical radiation flux to the double-nanohole structure can provide a folding and/or binding of protein molecules that can be identified based on changes in optical transmission. Varying nanohole transmissions can thus be associated with trapping, binding and unfolding of biological particles. The double-nanohole defines cusps, but such cusps can be defined in other ways as well.

System for trapping, interacting and modifying single protein molecules using a double-nanohole structure

The present invention presents a device and methods of use thereof in combined electrohydrodynamic concentration and plasmonic detection of a charged species of interest using a flow-through nanohole array. The device comprises microchannels, which are linked to a substrate with arrays of through nanoholes, wherein the substrate comprises two layers, wherein one of the layers is made of insulator material and one of the layers is made of metal, whereby induction of an electric field across the nanohole array results in the species of interest concentrating inside the nanoholes and in the vicinity of the nanohole arrays. The induction of an electric field is achieved by means of an external electric field source, which is applied to the fluid containing the species of interest, resulting in electroosmotic (EO) flow. An additional pressure driven fluid flow in the microchannels, co-directional to the EO flow is applied by external means. The resulting fluid flow from the combination of the EO and pressure driven flow results in a total bulk fluid flow hereafter referred to as bulk flow (BF). The local electric field strength across the insulator layer of the nanoholes is high and the charged species in the fluid may exhibit a high electrophoretic (EP) velocity, opposing the BF. The local field strength in the metallic portion of the nanoholes is null, due to the conducting nature of the metal, and the charged species in the fluid exhibits a null EP velocity in this region. The BF and the EP velocity of the charged species may be balanced which may result in the concentration of the charged species inside the nanoholes and at both sides of the nanohole array. An incident light over one side of the nanohole array may result in the formation of surface plasmons (SP) at the interface of the metal and the surrounding liquid containing the concentrated species. The signal from the SP may be detected by optical means, including surface plasmon resonance (SPR) imaging and SPR spectroscopy.

Flow through metallic nanohole arrays

Disclosed are devices and methods for enhancing the performance of photoconductive switches or photomixers used to generate or receive terahertz radiation. An interlaced electrode is used to minimize carrier transit times across an absorbing semiconductor photoconductor. This electrode is designed to support a plasmonic resonance such that coupling of the optical pump signal to the absorbing photoconductor is enhanced.

Interlaced terahertz transceiver using plasmonic resonance

Growing community of inventors

Victoria, Canada

Reuven Gordon