Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Reto Stöcklin

Vincent Dive

Bertrand Tavitian

Jordi Molgo

Fabrice Beau

Joël Cotton

Bertrand Czarny

André Menez

Philippe Favreau

Evelyne Benoit

The present invention relates to novel mu-conotoxin peptides, biologically active fragments thereof, combinations thereof and/or variants thereof. The invention also relates to their use in pharmaceutical composition for the treatment or prevention of pain, and their use in the preparation of an anesthetic.

Mu-conotoxin peptides and use thereof as a local anesthetic

The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least one animal; (2) at least one of the animals is slaughtered and the tissue distribution of the radioactivity of the molecules administered is analyzed in vivo; (3) sections of tissue or organs in which a radioactivity signal is detected are selected; (4) radioactive fractions from the sections of tissue or organs are isolated using suitable techniques such as chromatography and/or extraction techniques; and (5) the molecule(s) from the radioactive fractions obtained in step 4 are characterized using suitable analysis techniques such as chromatography and/or mass spectrometry.

Method of screening groups of radioactive molecules and applications thereof

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Bernex, Switzerland

Reto Stöcklin