Aarhus Universitet

René Søndergaard Nilsson

Anders Rosendal Korshøj

Peter Johansen

Peter Gorm Larsen

Systems and methods are provided for controlled infusion, effusion, and/or perfusion of biological/biocompatible liquid to and from a body cavity of a subject, and for continuous control of body cavity parameters, for example in neuro-intensive care. Systems and methods may relate to estimating compliance and pressure/volume changes within a body cavity. A bio-liquid replacement system may include a sensor for continuously measuring at least one parameter associated with the cavity, a pump for infusing the liquid into and aspirating the liquid out of the cavity, a processing unit continuously calculating at least one physiological parameter based on the measured parameter, and defining a target parameter slightly offset from the physiological parameter, and a flow controller controlling said pump unit based on the target parameter and the induced offset such that continuous compensatory changes are induced in the liquid volume. The processing unit continuously estimates the body cavity compliance.

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Aarhus V, Denmark

René Søndergaard Nilsson