Novartis Ag

Novartis Pharma Gmbh

René Hersperger

Philipp Janser

Wolfgang Miltz

Achim Schlapbach

Birgit Bollbuck

Lászlo Révész

Rudolf Wälchli

Emil Pfenninger

Hans Juerg Wuethrich

Jörg Eder

Alastair DenholmMritain

Rudolf Wálchi

Alastair Novartis Horsham Research Ctre Denholm

A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof, wherein the variants R, R9, Z, X, Q and Y are defined in the specification. 

Chemokine receptor antagonists

A compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof wherein the variables have the meanings as defined in the specification. Further disclosed are a method of inhibiting IKK activity using a compound of formula I, a method of inhibiting production of TNF using a compound of formula I, a compound of formula I for use as a pharmaceutical, a pharmaceutical composition comprising a compound of formula I, and use of a compound of formula I in the manufacture of a medicament for use as an immunosuppressant or anti-inflammatory agent. 

2-aminopyrimidine derivatives and their medical use

Growing community of inventors

Münchenstein, Switzerland

René Hersperger