Pfizer Corporation

Pfizer Products Inc.

Renuka Devi Reddy

Evgenyi Y Shalaev

Ravi Mysore Shanker

Carl Bernard Ziegler

Roger N Kimball

Roger Nelson Kimball

Simon Edward Blanchflower

Brian Scott Bronk

Evgenyi Yur'evich Shalaev

Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.

Process for annealing amorphous atorvastatin

Formulations containing an antibacterial alkali metal salt of a cephalosporin compound and methods of treating bacterial infections in dogs and cats.

Methods of treatment and formulations of cephalosporin

The invention provides methods of protecting solid-state proteins from the effects of ionizing radiation which comprise combining the protein with a radiation-protecting amount of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde; radiation-protecting amounts of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; or radiation-protecting amounts of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde and isopropanol, prior to exposing the protein to ionizing radiation. The invention further provides radiation-resistant pharmaceutical formulations comprising a protein and a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde; a protein and a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; or a protein and a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde and isopropanol. The invention still further provides a composition comprising a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, and for the use of such composition in pharmaceutical formulations as a radioprotectant.

Use of o-vanillin and o-vanillin/trolox combinations

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Waterford, CT, United States of America

Renuka Devi Reddy