Columbia University

Renjun Pei

Milan N Stojanovic

Jingyue Ju

Donald W Landry

Qiao Lin

ThaiHuu Nguyen

Chunmei Oiu

Steven Michael Forna Taylor

The described subject matter includes techniques and components for minimally invasive, selective capture and release of analytes. An aptamer is selected for its binding affinity with a particular analyte(s). The aptamer is functionalized on a solid phase, for example, microbeads, polymer monolith, microfabricated solid phase, etc. The analyte is allowed to bind to the aptamer, for example, in a microchamber. Once the analyte has been bound, a temperature control sets the temperature to an appropriate temperature at which the captured analyte is released.

Selective capture and release of analytes

Disclosed are aptamer/drug conjugate complexes and the use of such complexes, together with a trigger compound, to inducibly release a drug. Also disclosed are methods for establishing a drug reservoir in a subject using these complexes, whereby drug may be released as needed. One example of such a complex is an aptamer/insulin conjugate complex from which insulin may be released by an innocuous, orally administrable trigger, such as quinine.

Aptamer-mediated drug release

Growing community of inventors

Jiangsu, China

Renjun Pei