Shanghai Institute of Pharmaceutical Industry

Chinese Academy of Sciences

China State Institute of Pharmaceutical Industry

Shanghai Targetdrug Co., Ltd.

Renhai Chen

Ying Liu

Zhen Zhang

Quanhai Liu

Li Cai

Minyu Liu

Yifang Deng

Xiaoling Huang

Li Chen

Guoping Wang

Xuejun Wu

Lin Xiao

Xing Fan

Jinyao Chen

Guobin Ren

Yan Qin

Haiyan Sun

Zhiru Xu

Chungang Li

Yaqiu Long

Tian Zhang

Mianli Pan

Zhenpeng Yu

Shenrong Tang

Gouping Wang

Liling Jin

Xiangduan Tan

Dongzhi Feng

Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R, R, R, R, R, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

Amide compound, preparation method and uses thereof

An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.

Amorphous asiatic tromethamine salt and preparation method thereof

The present invention pertains to the field of pharmaceutical chemistry and discloses 8-(3-aminopropyl)-3-exo-8-azabicyclo[3.2.1]octane-3-amino amide compounds represented by formula I, the pharmaceutical compositions, the preparation method and the use thereof. Such compounds or pharmaceutically acceptable salts thereof can be used as an antagonist of CCR5 in preparing medicaments for treating diseases mediated by CCR5, particularly HIV infection, asthma, rheumatoid arthritis, autoimmune diseases and chronic obstructive pulmonary diseases (COPD). 

Amide compounds, their pharmaceutical compositions, their preparation method and their uses

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Shanghai, China

Renhai Chen