University of South Florida

King Abdulaziz University

Torrey Pines Institute for Molecular Studies

The UAB Research Foundation (the University of Alabama at Birmingham)

Renee Marie Fleeman

Lindsey Neil Shaw

Bill J Baker

Dennis Edward Kyle

Marcello Angelo Giulianotti

Radleigh G Santos

Ala Azhari

Danielle H Demers

Richard Allen Houghten

Adel Nefzi

Roman Manetsch

Charles Dunkle Amsler, Jr

James Bruce McClintock

David Lawrence Flanigan

Whittney Burda

Kurt Steven Van Horn

Megan M Barber

Witowski G Christopher

Jacqueline Lee Fries

Provided is a darwinolide compound having a previously undescribed carbon skeleton and the crystalline form thereof. Also provided are processes of isolating darwinolide, compositions comprising darwinolide, and methods of treating infection, such as a methicillin-resistantbiofilm infection.

MRSA biofilm inhibition

Disclosed herein are efflux pump inhibitors and pharmaceutical compositions comprising the same. The efflux pump inhibitors may be used in methods of preventing antibiotic resistance in a subject, and in methods of treating a bacterial infection in a subject. The efflux pump inhibitor may be co-administered with an antibiotic.

Polyamine compounds targeting the efflux pumps of multi-drug resistant bacterial pathogens and methods of using the same

Novel antimicrobial compounds against drug targets such as Eskape pathogens,, and cancer are presented herein.

Antimicrobials from an epigenetics based fungal metabolite screening program

Described herein are quinazoline-based compounds and formulations thereof. In some embodiments, the compounds and/or formulations thereof can be effective to inhibit and/or kill. Also described herein are methods of treating a subject in need thereof by administering to the subject in need thereof a quinazoline-based compound and/or formulation thereof to the subject in need thereof.

[object Object]

The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition (e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

Bis-cyclic guanidine compound compositions, methods of use and treatment thereof

The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition {e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

BIS-cyclic guanidine compound compositions, methods of use and treatment thereof

Growing community of inventors

Tampa, FL, United States of America

Renee Marie Fleeman