Leland Stanford Junior University

Parkinson's Institute

Renee Ann Reijo Pera

Barry Behr

Shawn L Chavez

J William Langston

James Anthony Byrne

Theodore D Palmer

David B Camarillo

Branden John Cord

Livia Zarnescu

Blake Byers

Jinnuo Han

Ha Nam Nguyen

Birgitt Schule

Kevin E Loewke

Birgitt Schüle

Sohyun L McElroy

Lynn M Westphal

Brooke Friedman

Paul J Turek

Juanito Meneses

Nina Kossack

Keh Kooi Kee

Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided.

Pluripotent cell lines and methods of use thereof

Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte.

Mechanical biomarkers for oocyte and embryo viability

Methods and compositions are provided for promoting germ cell differentiation from pluripotent cells, and for identifying agents that modulate germ cell differentiation.

Induction of germ cells from pluripotent cells

Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.

Methods of detecting aneuploidy in human embryos

Markers are provided for genetic and epigenetic diagnosis of embryos to determine those of which are more likely to be chromosomally normal and advance in development.

Markers for the detection of human embryo developmental quality

Methods are provided for the non-invasive imaging of embryos to determine whether they are euploid or aneuploid.

Non-invasive imaging to the blastocyst stage for the detection of human embryonic aneuploidy

A substantially pure population of human somatic cells that have enhanced potential to become induced pluripotent stem cells (iPS cells) is provided. Also provided are methods for generating this population of cells and methods for generating iPS cells from this population of cells.

Enhanced efficiency of induced pluripotent stem cell generation from human somatic cells

A method of in vitro maturation of adult human germ line cells in an artificial biological environment, which entails:

Human multipotent germ line stem cells expressing a germ line marker and a pluripotency marker produced by co-culture of testicular tissue

Growing community of inventors

Los Altos, CA, United States of America

Renee Ann Reijo Pera