Vaccinex, Inc.

Renee A Kirk

Ernest S Smith

Mark Paris

Angelica A Cornelison

Maurice Zauderer

Maria G M Scrivens

Tracy Pandina

Leslie A Croy

Leslie A Balch

Angelica Moksa

Pamela M Holland

Andrew Lake

Sonia G Das

Austin Dulak

Caroline Harvey

Maria Scrivens

Christopher Converse Wells

Angelika Moksa

The present disclosure is directed to antibodies or antigen-binding portions thereof that specifically bind human CCR8, polynucleotides and vectors encoding the same, and pharmaceutical compositions comprising the same. Some aspects of the disclosure are directed to methods of treating a disease or condition comprising administering the anti-CCR8 antibody to a subject in need thereof.

Anti-CCR8 antibodies and uses thereof

This disclosure provides compositions and methods for expressing and displaying isolated integral membrane proteins (IMPs) or fragments thereof in a native conformation for use in the screening, selecting, and identifying of antibodies or antibody-like molecules that bind to a target IMP of interest.

Integral membrane protein display on poxvirus extracellular enveloped virions

The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.

Method for selecting polynucleotides encoding antigen-specific immunoglobulin subunit

Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus

Method for selecting polynucleotides encoding antigen-specific immunoglobulin subunits

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Bloomfield, NY, United States of America

Renee A Kirk