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The Boots Company Plc

Rene Zalisz

Pierre Smets

Marie-France Salles

Armelle Bonfils

Abdel Karim Braham

Jean-Claude Drouet

Marie-Odile Martin

Dominique Biard

A method for facilitating the healing of skin comprising applying topically to skin a composition containing an amount of a lipopolysaccharide extracted from gram negative bacteria effective to facilitate skin healing.

Skin healing method

A sequence of anti-direction, anti-messenger RNA oligonucleotides of .alpha.-TNF characterized in that it possesses the structure of the formula ##STR1## wherein X is hydrogen, or a sequence of 1 to 17 oligonucleotides in free form, in alkylated form, in sulfurated form or in the form of a poly L-lysine derivative useful for stopping the production of .alpha.-TNF.

Oligonucleotides that inhibit production of .alpha.-tumor necrosis factor

A sulfate derivative of galactan extracted from Klebsiella mainly comprised of sulfate neutral oses in a proportion of 20 to 90% of hydroxyls and their preparation and method of use.

Sulfate derivatives of galactan extracted from Klebsiella

A dermatological hair growth stimulating composition containing an effective amount of a glycoprotein extract of gram negative bacteria as the growth stimulant and a method of stimulating hair growth.

Novel dermatological composition and method

A novel process for the preparation of water-soluble acyl glycoprotein extracted from Klebsiella Pneumoniae containing 30 to 45% by weight of proteins, 30 to 40% by weight of neutral saccharides, less than 4% of glucuronic acid, 2 to 5% by weight of osamines with a molecular weight of about 350,000 daltons and having a polysaccharide chain of n chains of one molecule of glucose and 4 molecules of galactose attached to an asparagine of a proteidic chain by a core formed of heptose and 2-keto-3-deoxy-octulosonic acid followed by an acyl portion containing .beta.-hydroxymyristic acid and then N-acetyl-glucosamine designated herein as F.sub.1 and compositions and a method of inducing antiallergic properties in warm-blooded animals.

Novel compositions and processes

An acylglycan extract of Klebsiella consisting essentially of about 80% of neutral oses, about 20% of lipids and less than 2% of proteins and having a molecular weight of approximately 12,500 and a process for obtining them which have antiallergic and immunomodulating properties.

Acylglycan extracts of Klebsiella

Novel water-soluble, immunostimulating glycoproteins extracted from Klebsiella pneumoniae containing 30 to 45% by weight of proteins, 30 to 40% by weight of neutral saccharides, up to 4% by weight of glucuronic acid, 2 to 5% by weight of osamines and having a molecular weight of about 350,000 daltons.

Novel immunostimulating glycoproteins

Immunostimulating glycoproteins

Novel water-soluble, immunostimulating glycoproteins extracted from Klebsiella Pneumoniae containing 20 to 35% by weight of proteins, 50 to 70% by weight of neutral monosaccharides, 3 to 8% by weight of glucuronic acid, 1.5 to 3% by weight of osamines and having a molecular weight greater than 100,000 daltons.

Novel glycoproteins

Novel water-soluble glycoproteins isolated from Hafnia strain having remarkable anti-inflammatory and immunostimulating activity with very good tolerance and their preparation.

Growing community of inventors

Menucourt, France

Rene Zalisz