Koninklijke Philips Corporation N.v.

Rene Van Den Ham

Bart Jacob Bakker

Hendrik Jan Van Ooijen

Wilhelmus Franciscus Johannes Verhaegh

Henk Jan Van Ooijen

Sergey Kurkin

Herman Sontrop

The invention relates to a method for predicting a value of a parameter of a system (). The value of the parameter of the system () is predicted by incrementally optimizing a pharmacokinetic and pharmacodynamic model based on values of parameters of the system () received over time. This allows for predicting values of the parameters of the system () with improved accuracy. In one embodiment the system () comprises a coagulation system () comprising an anticoagulant. The predicted value of the parameter of the system () can be a point in time at which the coagulation system () reaches hemostatic balance after a periodic supply of anticoagulant to the coagulation system () is discontinued.

Incrementally optimized pharmacokinetic and pharmacodynamic model

The present invention relates to clinical decision support systems. In detail, the present invention relates to a method for determining the initial fibrinogen concentration in a biological sample, to the use of fibrinogen added to a biological sample in at least one predetermined concentration, to a device for determining the initial fibrinogen concentration in a biological sample, to a computer program comprising program code means for causing a computer to carry out at least several steps of the method according to the invention, to a computer readable non-transitory storage medium containing instructions for carrying out at least some steps of the method according to the invention, and to a kit for determining the initial fibrinogen concentration in a biological sample.

Method for determining the fibrinogen concentration in a biological sample

The present invention provides for a simultaneous graphical representation, a risk of bleeding and a risk of thrombosis providing a visualized bridge therapy process. Furthermore, the present invention provides for a computer-based prediction of the haemostatic situation of the examined blood circulation by using a combination of a biochemical model and a pharmacokinetic model for calculation or another mathematical representation of the blood circulation.

Method of visualizing a bridge therapy process

A method for estimating concentrations or concentration changes of particular biological markers, e.g. proteins, includes performing estimations by providing a mathematical model with data from measurements of other biological markers, e.g. other proteins. Thus, instead of measuring the concentration of particular proteins, this concentration can be estimated using the model. The estimated proteins can be used together with other clinical data in another model which is able to provide information or estimations of a patient's disease, for example.

Estimation of diagnostic markers

A classification system () for classification of bio molecular data is provided. An input of the system receives a plurality of features () of a sample to be classified and a plurality of respective error estimates (). A statistical module () associates probability density functions () with the features, wherein variances of the probability density functions depend on the error estimates. A replication module () produces a plurality of perturbed replicas () of the sample, wherein the features are randomly perturbed according to the corresponding respective probability density functions. A classifier () classifies the perturbed replicas based on the perturbed features. An analyzer () classifies the sample to be classified based on a statistical analysis of the classified replicas () to obtain a sample classification ().

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Eindhoven, Netherlands

Rene Van Den Ham