Leiden University Medical Center

Inova Diagnostics, Inc.

Keygene N.v.

René Toes

Jan Wouter Drijfhout

Leendert Adrianus Trouw

Michael Mahler

Peter Van Veelen

Tom Huizinga

Rienk Offringa

Stephen P Schoenberger

Cornelis J M Melief

The present disclosure relates to the field of molecular biology and more specifically to methods for detecting anti-carbamylated protein (anti-CarP) antibodies in the serum of rheumatoid arthritis (RA) patients.

Compositions and methods for the diagnosis of rheumatoid arthritis

Disclosed is a method and composition for treating tumors or infectious diseases, wherein the composition includes CD40 binding molecules together with CTL-activating peptides, e.g., tumor antigens. Such composition is useful for enhancing the anti-tumor effect of a peptide tumor vaccine, or for otherwise activating CTLs so that the activated CTLs can act against tumorous or infected cells. The CD40 binding molecules can include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, (Fab')and Fv, as well as other molecules including peptides, oligonucleotides, peptidomimetics and organic compounds which bind to CD40 and activate the CTL response.

CD40 binding molecules and CTL peptides for treating tumors

Growing community of inventors

Leiden, Netherlands

René Toes