Ortho-mcneil Pharmaceutical Corp.

Rene Huvar

Mark G Erlander

Adrienne Dubin

Arne Huvar

Lukas K Buehler

Jayashree Pyati

DNA encoding human 5-HT3-C has been cloned and characterized. The recombinant protein is capable of forming biologically active human 5-HT3-C protein. The cDNA has been expressed in recombinant host cells that produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

Human 5-HT3-C protein

DNA encoding human acid sensing ion channel BnaC4 has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

DNA encoding human acid-sensing ion channel BNaC4 (ASIC4)

DNA encoding a human subunit 5-HT3-C of the 5-HT3 serotonin receptor

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Bmo-Komin, Czechia

Rene Huvar