Sandoz Gmbh

Rene Huguenin

Janos Pless

Wilfried Bauer

Francois Cardinaux

Edmond Sandrin

Somatostatine derivatives of the general formula ##STR1## wherein either (a)

Somatostatine derivatives

The invention provides polypeptides of formula I,

Organic compounds

Pentapeptides of formula I, ##STR1## wherein Z.sup.1 =H, CH.sub.3 or amidino; R.sub.1 =H or alkyl and R.sub.2 =H or R.sub.1 +R.sub.2 =--CH.sub.2 --CH.sub.2 --; R.sub.3 =m- or p--OH or -alkoxy; B=residue of a (D)-.alpha.-amino acid; R.sub.4 =H or alkyl; Z.sup.2 =optionally substituted phenyl; and E=.beta.-amino alcohol residue (whereby when Z.sup.1 =H or CH.sub.3, R.sub.4 =C.sub.3-4 -alkyl) as well as their esters and the acid addition salts and complexes of such peptides and esters. Compounds according to the invention have valuable pharmacological, in particular LH-secretion inhibiting activity.

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Reinach, Switzerland

Rene Huguenin