Bioetica, S.a.

Other

Coletica

Societe Anonyme, Bioetica

Rene Gimeno

Alain Roger Huc

Daniel Herbage

Pierre DeVictor

Patrick Le Pivert

A process of preparation of collagen containing in major proportion insoluble collagen is disclosed, including rinsing and washing the collagenic tissue, acidifying the ground material pH value 1 to 4 to get a collagenic paste which is diluted in a diluting solution to get the collagen gel having a concentration in collagen lower than about 2.5 by weight expressed in dry collagen, and performing a shearing stirring at high speed producing ultrasonic effect to get a substantially homogeneous collagenic gel. The collagen has improved mechanical resistance and thermal stability.

Process of preparation of collagen containing in major proportion

This invention relates to a process and apparatus for freeze-drying, said apparatus comprising freeze-drying shelves disposed inside a freeze-drying enclosure, on which may be placed products or solutions to be freeze-dried, which may be contained in open recipients, as well as cooling and/or heating means associated with and preferably incorporated in said shelves, wherein means forming a thermal shield are disposed between said freeze-drying shelves, thus making it possible to slow down the heat exchanges between the surface of the product to be freeze-dried and the heating and/or cooling elements associated with the shelves. More homogeneous freeze-dried products are obtained in this way.

Process and apparatus for freeze-drying comprising means forming an

An apparatus for the production of a collagen tube to be used as a vascular prostheses or nerve suture, including a cylindrical tubular spinneret having a feed end for an aqueous solution of collagen gel and a discharge end and a coagulant tube concentrically disposed in the spinneret with all around circumferential clearance and terminating upstream of the discharge wherein a tube of aqueous acid collagen gel is extruded through the clearance around the coagulant tube. The coagulant tube has its inner wall contacted with a coagulating solution emerging therefrom before the tube of aqueous collagen gel reaches the discharge end of the cylindrical tubular spinneret. The discharge end of the tubular spinneret terminates in a bath of coagulating solution and a bed is disposed in the bath to receive the extruded collagen tube from the end of the tubular spinneret. The tubular spinneret is capable of being displaced with respect to the bath.

Apparatus for the extrusion of collogen tubes

A process for preparing collagen tubes includes extruding an aqueous gel containing about 1.5% native collagen through a cylindrical spinneret equipped with a central concentric tube designed to receive a part of a coagulation bath, followed by coagulation of the internal and external walls of the tube, leaving the spinneret in a coagulation bath constituted by about 70% acetone and 30% ammonia, followed by drying. Following drying, the collagen tube may be subjected to reticulation by dehydration carried out at about 80.degree. C. under a pressure of about 0.1 mm of Hg (vacuum) for about 24 hours. The reticulated collagen tube may eventually be subjected to a treatment which permits the introduction of azide groups onto the molecule without requiring that the collagen be coupled to any external molecule.

Process for the preparation of collagen tubes

A new sustained-release, microencapsulated pharmaceutical composition is disclosed, suitable for oral administration which contains an effective amount of an orally-administered pharmaceutical in granular form wherein the granules are coated by a layer of homogeneous, native collagen to encapsulate the granules. Also disclosed is a method for administering the sustained-release compositions and a process for covering the granulated pharmaceutical with the layer of homogeneous, native collagen.

Forms of microencapsulation of medicinal substances by homogeneous

Biocompatible reservoirs are constituted by collagen, optionally associated with mucopolysaccharides and/or gelatin; these reservoirs can be filled with an active principle which does not have to be mixed with collagen. The reservoirs can be employed to either hold or to emit one or more active principles in order to concentrate same and/or to distribute same at a controlled rate 'in vitro' and/or 'in vivo'. The reservoirs thus are enclosed vessels of conseration of 'in vitro' or 'in vivo' cultures of cells, bacteria or viruses.

Implantable, biocompatible reservoirs permitting conservation, cellular

A new process is disclosed for obtaining homogeneous layers of native collagen. Also disclosed is a new process for covering a support with a homogeneous layer of native collagen as well as supports covered thereby.

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Pelussin, France

Rene Gimeno