The Netherlands Cancer Institute

Merck Sharp + Dohme Corp.

Rosetta Inpharmatics, Inc.

Rene Bernards

Peter S Linsley

Yudong He

HongYue Dai

Christopher J Roberts

Laura Johanna Van't Veer

Mao Mao

Marc J Van De Vijver

Augustinus A M Hart

A A M Hart

Aa M Hart

Laura Johanna VAN'T Veer

The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

Diagnosis and prognosis of breast cancer patients

The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also provides methods of classifying and treating patients based on prognosis. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the diagnostic, prognostic and statistical methods disclosed herein.

Methods of assigning treatment to breast cancer patients

Growing community of inventors

Abcoude, Netherlands

Rene Bernards