Societa Italo-britannica L. Manetti-h. Roberts & C.

Societa Italo-britannica-l. Manetti-h. Roberts Co.

Renato Selleri

Giovanni Orzalesi

The object of the invention is a new chemical compound 2-(4- isobutylphenyl)propiohydroxamic acid, having valuable analgesic, antipyretic and antiinflammatory properties, and a procedure for its synthesis.

2-(4-Isobutylphenyl)-propiohydroxamic acid and a procedure for its

2-(4-Isobutylphenyl)-propiohydroxamic acid is prepared by mixing anhydrous methanol with 2-(4-isobutylphenyl)-propionitrile, saturating the mixture with dry hydrogen chloride, reacting, diluting the reaction product with ethyl ether, reacting the precipitate with hydroxylamine hydrochloride in methanol and with 50% NaOH, stirring, diluting with water and precipitating with carbon dioxide.

Process for the preparation of 2-(4-isobutylphenyl)-propiohydroxamic acid

There is prepared the compound N,N'-bis-(3-picolyl)-4-methoxy-isophthalamide. It is useful as an inhibitor of blood plate aggregation.

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Florence, Italy

Renato Selleri