The Salk Institute for Biological Studies

Icahn School of Medicine at Mount Sinai

Sanford-burnham Medical Research Institute

Renate König

Peter M Palese

Adolfo Garcia-Sastre

Sumit K Chanda

Megan Shaw

John Young

Silke Stertz

This application relates to the modulation of host cell factors required for influenza virus replication. The application relates to compounds, including nucleic acid compounds (such as, e.g., small interfering RNAs (siRNAs)) and small molecules, that target human host cell factors involved in influenza virus replication, and the use of such compounds for modulating influenza virus replication and as antiviral agents. The application also relates to methods of treating an influenza virus infection and methods of treating or preventing a symptom or disease associated with influenza virus infection, comprising administering to a subject a composition comprising a compound, such as a nucleic acid compound (e.g., an siRNA) or small molecule, that targets a human host cell factor involved in influenza virus replication.

Compositions and methods for inhibiting human host factors required for influenza virus replication

Growing community of inventors

San Diego, CA, United States of America

Renate König