Pliva-istrazivacki Institut D.o.o.

Fidelta D.o.o.

Selvita D.o.o.

Renata Rupcic

Milan Mesic

Dijana Pesic

Gordon Saxty

Antun Hutinec

Goran Kragol

Dinko Ziher

Ivaylo Jivkov Elenkov

Andrea Fajdetic

Visnja Poljak

Zorica Marusic Istuk

Maja Matanovic Skugor

Sanja Kostrun

Kristina Butkovic

Marko Duksi

Ivana Ozimec Landek

Mirjana Bukvic

Mladen Mercep

The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.

Seco macrolide compounds

The present invention relates to 1,3-diaza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumor necrosis factor-&#x3b1; (TNF-&#x3b1;) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof

Growing community of inventors

Zagreb, Croatia

Renata Rupcic