Pliva-istrazivacki Institut D.o.o.

Fidelta D.o.o.

Selvita D.o.o.

Renata Rupcic

Milan Mesic

Dijana Pesic

Gordon Saxty

Antun Hutinec

Goran Kragol

Dinko Ziher

Andrea Fajdetic

Ivaylo Jivkov Elenkov

Visnja Poljak

Zorica Marusic Istuk

Kristina Butkovic

Ivana Ozimec Landek

Marko Duksi

Sanja Kostrun

Mirjana Bukvic

Maja Matanovic Skugor

Mladen Mercep

The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.

Seco macrolide compounds

The present invention relates to 1,3-diaza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumor necrosis factor-&#x3b1; (TNF-&#x3b1;) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof

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Zagreb, Croatia

Renata Rupcic