Capsulis

Capsules

Ren&eacute; Laversanne

Didier Roux

Jo&euml;lle Amedee

Corinne Degert

Charles Guinez

OLivier Freund

Patrick Mahy

A method for oral administration of an active principle includes the steps of incorporating an active principle in multilamellar vesicles having a diameter of between 0.1 and 25 &mgr;m, and a lamellar liquid-crystal internal structure formed, from the center to the periphery of the vesicles, of a stack of concentric bilayers based on amphiphilic agents alternating with layers of water, aqueous solution or solution of a polar liquid, and orally administering a composition containing the active principle incorporated within the vesicles.

Pharmaceutical compositions for oral administration

A composition containing a plurality of multicellular vesicles and at least one nucleic acid, at least one part of which is found included inside the multilamellar vesicles. Each of the vesicles is formed of a succession of lamellar bi-layers extending from each vesicle center to its periphery and including at least one surfactant agent. The bi-layers are concentric and are separated by a liquid medium. Such compositions can be used in pharmaceutics, particularly gene therapy, and in in vitro and in vivo transfection.

Compositions containing at least one nucleic acid

Method of making a product adhere to a surface, in which a composition is brought into contact with the surface, the composition containing the product incorporated in substantially spherical, multilamellar vesicles, with a diameter of between 0.1 and 100 &mgr;m, and including concentric membranes based on at least one surfactant and separated by a solvent medium. Each of the vesicles has an onion-like structure formed of a succession of concentric bi-layers extending from each vesicle center to its periphery, and containing therein at least one cationic agent, resulting in the vesicles carrying a positive overall charge.

Method for making a product adhere to a surface

Growing community of inventors

Pessac, France

René Laversanne

Growing community of inventors

Pessac, France

Ren&eacute; Laversanne

René Laversanne