University of Southern California

Other

Ren Liu

Parkash S Gill

Amy S Lee

Valery Krasnoperov

Parkash Gill

This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

Epitope specific antibodies that bind cell surface GRP78 and their use for cancer detection

Antibodies that bind cell surface GRP78

In certain embodiments, this present invention provides methods of identifying and using antibodies that act as either agonists or antagonists of Delta-like 4 (Dll4) signaling.

Methods for using and identifying modulators of Delta-like 4

Growing community of inventors

Azusa, CA, United States of America

Ren Liu