Institut National De La Sante Et De La Recherche Medicale

Sanofi

C M Industries

Remy Guegan

Joseph Diaz

Dino Nisato

Jean Wagnon

Pierre Corvol

Jean-Pierre Gagnol

Catherine Cazaubon

Colette Lacour

Genevieve Evin

Bernard Castro

The present invention relates to peptide amino-alcohol derivatives containing a tetra substituted carbon atom. Said peptides inhibit the renin and acid proteases. The invention also relates to the process for their obtention and to pharmaceutical compositions.

Peptide amino-alcohol derivatives containing a tetrasubstituted carbon

The present invention relates to peptide derivatives of the general formula:

Acid-protease inhibiting peptide derivatives

The present invention relates to a new process for the stepwise preparation of somatostatin enabling a product of high purity to be obtained, with high yields, from cysteine in 14 position whose acid function is protected by the phenylazobenzylsulfonylethyloxy group and thiol function is protected by the acetamidomethyl group, all the peptide coupling reactions being effected in liquid phase in the dimethylformamide, the intermediate peptides being precipitated by addition of a second solvent and purified in solid phase by washing with the aid of suitable solvents dissolving the impurities.

Process for the preparation of somatostatin

Growing community of inventors

Castelnau le Lez, France

Remy Guegan