University of Michigan

Remy Elbez

Raoul Kopelman

Brandon H McNaughton

Roy Clarke

Paivo Kinnunen

Alan Hunt

Theodore Albertson

Ariel Hecht

Irene Sinn

Identification, quantification and characterization of biological micro- and nano-systems is enabled by magnetically spinning these natural, non-magnetic systems with the aid of induced magnetization. Biofriendly magnetic micro- and nano-labels enable magnetorotation in extremely weak electromagnetic fields. The spinning of these micromotors can be observed by a simple, CD-like, optical tracking system. The spinning frequency response enables real-time monitoring of single (cancer) cell morphology, with sub-microscopic resolution, yielding previously undeterminable information. Likewise, it enables super-low detection limits for any (cancer) biomarker.

Magnetically induced microspinning for super-detection and super-characterization of biomarkers and live cells

Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is descried. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also described herein are methods for controlling the illumination and imaging of rotating magnetic particles.

Asynchronous magnetic bead rotation sensing systems and methods

Growing community of inventors

Ann Arbor, MI, United States of America

Remy Elbez