Pierre Fabre Medicament

Rémi Rabot

Karim Bedjeguelal

El Bachir Kaloun

Nicolas Rahier

Anna Kruczynski

Philippe Schmitt

Patrice Mayer

Hugues Bienayme

Michel Perez

Arnaud Marchand

Stéphane Poigny

Houcine Rahali

Serge Grisoni

Rachid Rahali

Laurent Creancier

Antoine Dumoulin

Bachir Kaloun El

Eric Tam

Pascaline Klein

Emmanuel Fournier

Philippe Schambel

Hugues Bienhayme

The present invention relates to a compound of following formula (I) or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture, as well as pharmaceutical composition comprising such a compound, for use in the treatment of a cancer associated with the overexpression of at least one Trk protein. 

Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing Trk

The present invention relates to compounds of following general formula (I): and to the pharmaceutically acceptable salts of same, the tautomers of same, the stereoisomers or mixture of stereoisomers in any proportions of same, such as a mixture of enantiomers, notably a racemic mixture, as well as to methods for preparing same and uses of same, notably as an antineoplastic agent. 

Tri- and tetracyclic pyrazolo[3,4-B]pyridine compounds as antineoplastic agent

The present invention concerns compounds of following general formula (I): (Formula I) and their pharmaceutically acceptable salts, their method of preparation and their uses, notably as anticancer agent. 

Pyrazolopyridine derivatives as anticancer agent

The present invention relates to a compound of following formula (I): or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture; as well as to the use of same as a drug, notably intended for the treatment of cancer, inflammation and neurodegenerative diseases such as Alzheimer's disease; to the use of same as a kinase inhibitor; to the pharmaceutical compositions comprising same; and to methods for the preparation of same.

Substituted pyrazolo[3,4-b]pyridines as medicaments

The present invention relates to inhibitors of protein kinases of formula I: which can be used in the treatment of various diseases, notably cancer, inflammation or disorders of the central nervous system. It also relates to pharmaceutical compositions containing the compounds according to the invention and their use in therapy.

Pyrroloquinoline derivatives and their use as protein kinases inhibitors

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Toulouse, France

Rémi Rabot