Biodex

Remi Huynh

Jacqueline Jozefonvicz

Marcel Jozefowicz

Frederic Chaubet

Jose Correia

Latifa Dahri

Latifa Dahri-Correia

The invention concerns dextran derivatives, their applications as medicines with specific biological action, and their preparation method. Said derivatives correspond to the general formula DMC B SU S , in which: D represents a polysaccharide chain, preferably consisting of sequences of glucoside units, MC represents methylcarboxylate groups, B represents carboxymethylbenzylamide groups, Su represents sulphate groups, S represents sulphonate groups, a, b, c and d represent the degree of substitution (ds), respectively in groups, MC, B, Su and S; a being equal to 0 or &gE;0.3, b being equal to 0 or &gE;0.1, c being equal to 0 or &gE;0.1 and d being equal to 0 or &gE;0.1 provided that when d&equals;0, a and/or b are not equal to 0, said products having homogeneity of chain size distribution, illustrated by a gauss elution profile symmetrical in high performance steric exclusion chromatography, and homogeneity in the distribution of charged chemical groups, illustrated by an elution profile with a single symmetrical peak in low pressure ion-exchange chromatography.

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Saint-Amand-les-Eaux, France

Remi Huynh