Technology Resources International Corporation

Primamedic, Ltd

Petrovax, L.l.c.

Rem V Petrov

Larissa A Fonina

Rakhim Musaevich Khaitov

Arkady Vasilievich Nekrasov

Agusta A Mikhatlova

Stanklav Jn Shanurin

Augusta A Mikhailova

Sergei A Guriyanov

Sergey A Gur'yanov

Elena A Kirilina

Emma K Daugalieva

Ludmila A Zakharova

Ravshan I Ataullakhanov

The present invention pertains to peptides comprising 4 to 10 amino acids including X -Pro, Pro-X or X -Pro-X , wherein X and X are independently selected from Lys, Arg, His, Asp, Glu, Asn and Gin, and the other amino acids are independently selected from Gly, Ala, Val, Leu, Ile, Nle, Nva, Pro, Phe, Tyr, Trp, Cys, Met, Ser and Thr. Such peptides, including LVCYPQ (SEQ ID NO: 3), FRPRIMTP (SEQ ID NO: 4), VVYPD (SEQ ID NO: 5) and VDPP (SEQ ID NO: 6), are obtainable from porcine bone marrow cell culture, and have immunostimulating and anti-viral properties.

Myelopeptides and their therapeutic use

A compound for protecting a vertebrate against infection by helminths comprising hyaluronidase covalently coupled to an immunostimulating carrier, in preferred form, the immunostimulating carrier to which the hyaluronidase is covalently coupled comprising a copolymer of ethylenepiperazine N-oxide and N-ethylacetylethylenepiperazinium bromide (hereafter referred to as 'SYNPOL'), and a process for protecting a vertebrate against infection by helminths comprising administration to the vertebrate of a therapeutically effective amount of a compound comprising hyaluronidase covalently coupled to an immunostimulating carrier, preferably SYNPOL, in preferred form, the compound being administered to the vertebrate in the form of a vaccine.

Compounds for the prevention and treatment of helmith infections

The hexapeptide Phe--Leu--Gly--Phe--Pro--Thr, which is derived from a myelopeptide, exhibits immunostimulatory activity when administered to a mammal.

Hexapeptide having immunostimulatory activity

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Moscow, Russia

Rem V Petrov