University of Massachusetts

Reka Haraszti

Anastasia Khvorova

Neil Aronin

Matthew Hassler

Anton A Turanov

Mehran Nikan

Maire Osborn

Andrew Coles

Marie Cecile Didiot

Annabelle Biscans

Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.

Conjugated oligonucleotides

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobically modified oligonucleotide cargo, and uses thereof, are also provided.

Exosomal loading using hydrophobically modified oligonucleotides

Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.

Bioactive conjugates for oligonucleotide delivery

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

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Tubingen, Germany

Reka Haraszti