The Scripps Research Institute

University of Florida Research Foundation, Incorporated

Reji Nair

William R Roush

Thomas D Bannister

Andy Tsai

John L Cleveland

Jun Yong Choi

Jitendra K Mishra

Andy S Tsai

The invention provides compounds of formulae A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.

Heterocyclic inhibitors of monocarboxylate transporters

The invention provides heterocyclic compounds of formula A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.

The invention provides compounds that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.

Heterocyclic inhibitors of monocarboxylate transporter

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Palm Beach Gardens, FL, United States of America

Reji Nair