Ischemix, LLC

Therabite Corporation

Other

Innoves, Inc.

Reinier Beeuwkes

Steven A Kates

Alexander Baguisi

Alan S Lader

Ralph Casale

David A DeWahl, Jr

Alexander B Baguisi

Harold E Clupper

Thomas E Salisbury

Robert C Gorin

David Dewahl

The present invention relates, in certain embodiments, to methods for preventing and/or treating neurodegenerative damage (e.g., secondary cascade of neurodegenerative damage) and improving functional outcomes (e.g., outcomes associated with cognitive, behavior and sensorimotor function) caused by traumatic brain injury using neuroprotective lipoyl compounds. The present invention also provides, in various embodiments, compositions for use in treating and/or preventing TBI in a subject in need thereof, compounds for use in the manufacture of a medicament for treating and/or preventing TBI in a subject in need thereof, and methods of preparing a pharmaceutical composition for treating and/or preventing secondary brain damage caused by TBI.

Compositions and methods for treating traumatic brain injury

The present invention relates to compositions comprising a substantially pure compound represented by Structural Formula I: and methods of using such compounds to activate cytoprotective kinases. The values and preferred values of the variables in Structural Formula I are defined herein.

Compositions and methods for treating ischemia and ischemia-reperfusion injury

The present invention relates, in various embodiments, to a compound represented by Structural Formula (I), pharmaceutically acceptable salts or prodrugs thereof, and compositions comprising said compounds, or pharmaceutically acceptable salts or prodrugs thereof. Methods of using compounds of Structural Formulas (I) and (Ia) or compositions comprising compounds of Structural Formulas (I) and (Ia), or pharmaceutically acceptable salts or prodrugs thereof, to treat ischemia or ischemia-reperfusion injury are also disclosed.

Lipoyl compounds and methods for treating ischemic injury

The present invention relates, in various embodiments, to a compound represented by Structural Formula (I), pharmaceutically acceptable salts or prodrugs thereof, and compositions comprising said compounds, or pharmaceutically acceptable salts or prodrugs thereof. Methods of using compounds of Structural Formulas (I) and (la) or compositions comprising compounds of Structural Formulas (I) and (la), or pharmaceutically acceptable salts or prodrugs thereof, to treat ischemia or ischemia-reperfusion injury are also disclosed.

Lipoyl compounds and their use for treating ischemic injury

The present invention relates, in some embodiments, to compositions comprising a substantially pure compound represented by Structural Formula (I) and methods of using such compounds to activate cytoprotective kinases. In additional embodiments, the invention relates to methods for treating an ischemia or an ischemia-reperfusion injury in a subject, comprising administering to the subject an effective amount of a compound of the invention (e.g., in multiple doses). The values and preferred values of the variables in Structural Formula (I) are defined herein. 

The present invention relates to compositions comprising a substantially pure compound represented by Structural Formula II: and methods of using such compounds to activate cytoprotective kinases.

A translator apparatus for achieving omnidirectional translation of the mandible of a human patient and having a maxillary translation plate having a maxillary mouthpiece thereon for temporarily fixing the maxillary dentition of a patient thereto. A mandibular translation plate is provided, also having a mandibular mouthpiece for temporary fixation with the mandibular dentition of the patient and the mandibular element. A translation control plate is interposed between the maxillary and mandibular translation plates and establishes linearly moveable guiding relation with elongate guide slots of both the maxillary and mandibular plates. The guide slots of the respective translation plates which may be straight or of curved configuration are arranged in 90 degree relation to permit relative omnidirectional translatory positioning and movement of the translation plates for consequent selective omnidirectional therapeutic or diagnostic positioning or movement of the mandible of a patient. A translation actuator is supported by one of the translation plates and has mechanical interaction with the maxillary and mandibular translation plates and is operative to establish protrusive, retrusive and lateral movement of the mandibular plate and mouthpiece for corresponding omnidirectional protrusive, retrusive and lateral therapeutic movement of the mandible of the patient or for diagnostic positioning and movement of the mandible.

Passive mandible translator

Apparatus is provided for applying heat/cold to selected target regions of the human anatomy such as the temporalis and masseter muscles and to the region of the temporo-mandibular joint of the human cranial anatomy as well as other selected regions of the human anatomy such as the shoulders, knees, etc. At least one heat/cold compliant thermal cell is defined by a rigid back having a thin and compliant membrane connected thereto and defining a chamber for containing a substantial volume of a liquid or semi-liquid such as water or a gel, at a preselected temperature. The rigid back or shell defines a circumferential rim to which the compliant membrane is secured. The compliant membrane may have a side wall portion extending in substantially contiguous relation from the rim of the rigid shell and incorporates an integral substantially planar front wall portion which establishes intimate face-to-face heat/cold transferring relation with an anatomical target region. The membrane will engage the target region with low pressure per unit area and thus will readily conform to the configuration of the target region. The rigid shell defines a liquid inlet/outlet opening which is provided with a removable closure enabling heated or cooled liquid to be poured into or from the internal compartment. The thermal cell may include a heating or cooling system to enable prolonged therapeutic use. The thermal cell is adapted for releasable assembly with a support device such as a headband so that therapy may be conducted in hands-free manner. The headband assembly provides for a wide range of adjustment for selective location of the thermal cell and also provides substantially omnidirectional support so that the thermal cell can be readily oriented in conformance with the anatomical target region.

Apparatus for application of heat/cold to target regions of the human

An adhesive bound pad of paper such as loose leaf binder paper is provided which is secured in assembly by adhesive material, lining or partially lining holes along selected edges of the paper stack forming the pad. The edges of the paper pad remain free of adhesive material and thus are not distorted upon separation of the sheets from the pad. The adhesive bound pad is manufactured by assembling a selected number of sheets of paper into a stack and drilling or otherwise forming holes, such as binder holes, along one of the edges of the stack. Thereafter, the coating of adhesive material is applied within the holes of the stack so as to entirely coat the paper at the holes or to coat selected portions of the paper at the holes as desired. After the adhesive material has been allowed to cure or has been cured the paper is releasably retained in adhesive bound pad form and the manufacturing process is complete. Individual sheets of paper may be pulled away from the pad. The adhesive material may also provide reinforcement for the paper at the hole, especially in the case of loose leaf binder paper.

Adhesive bound pad of paper and method of manufacture thereof

A self-retaining staple construction is provided having a retainer bridge from which extend a pair of spaced, sharp pointed staple legs which are capable of penetrating a structure. The staple is provided with opposed inwardly directed retainer projections which permit assembly of the staple construction to an object and which retain the staple in assembly with the object. These retainer projections may be defined by resilient or rigid retainer members and may include an adhesive composition for securing the staple to an object.

Self retained stapled construction

A measurement device is provided for measuring the degree of mandibular movement during therapy following maxillofacial surgery or to otherwise accomplish measurement of jaw movement. The measurement device is in the form of a flat object having a rounded end and defining a reference depression for receiving the incisal edge of the teeth of either the mandibular or maxillary arches. The measurement device includes a curved end and a slightly curved top which are provided with indicia to indicate the degree of jaw opening by comparing the location of an incisal edge with respect to the indicia. The measurement device along a straight end is provided with measurement indicia to enable effective measurement of lateral jaw movement and to accomplish measurement of movement relative to the occlusal plane of the patient's dentition.

Growing community of inventors

Concord, MA, United States of America

Reinier Beeuwkes