Basf Se Corporation

Ciba Specialty Chemicals Corporation

Teva Pharmaceutical Industries Limited

Reinhold Öhrlein

Gabriele Baisch

Martin Studer

Stephan Burkhardt

Frank Bienewald

Barbara Wagner

Nicole End

Walter Fischer

Bernd Herzog

Hans Jürg Kirner

Kai-Uwe Schöning

Albert Schneider

Margherita Fontana

Oliver Reich

Jemima Schmidt

Alexander Mantler

Hans Jörg Kirner

Gerardus De Keyzer

Andreas Buthe

Tunja Jung

Andreas Mühlebach

Jonathan Rogers

Gisèle Baudin

Liliana Craciun

Barbara Winkler

Werner Baschong

Orest Polishchuk

Kai Eichin

Sébastien Mongiat

Peter Simmendinger

Laurent Michau

Thomas Giesenberg

Vilas N Mumbaikar

George William Schriver

Stephanie Portmann

Sandra Franziska Mayer

Described is the use of benzotropolone and their derivatives, especially the compounds of formula (1); wherein R, R, R, Rand Rindependently of one another are hydrogen; OH; C-Calkyl, C-Cal-kenyl, C-Calkoxy, C-Ccycloalkyl or CChydroxyalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C-Caryl, which may be substituted by one or more G; C-Cheteroaryl, which may be substituted by one or more G, C-Calkenyl, C-Calkynyl, C-Caralkyl, CN, or &#x2014;CO&#x2014;R; C-Cmono- or dialkylamino; COR; COOR; CONRR; CN; SOR; OCOOR; OCOR; NHCOOR; NRCOR; NH; *&#x2014;(CO)&#x2014;NH&#x2014;(CH)&#x2014;(PO)&#x2014;(OR); &#x2014;(CO)&#x2014;O&#x2014;(CH)&#x2014;(PO)&#x2014;(OR); sulphate; sulphonate; phosphate; phosphonate; &#x2014;(CH)&#x2014;[O&#x2014;(SO)]&#x2014;OR; &#x2014;O&#x2014;(CH)(CO)&#x2014;R; &#x2014;(O)&#x2014;(CH)&#x2014;(PO)&#x2014;(OR); &#x2014;(O)&#x2014;(CH)&#x2014;SO&#x2014;OR; halogen; organosilanyl; organo-siloxanyl; or a sugar residue linked directly in an &#x3b1;- or &#x3b2;-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH)&#x2014;(X)-benzotropolone system, wherein n=1-10 and X&#x2550;&#x2014;O&#x2014;; &#x2014;(CO)&#x2014;; &#x2014;O&#x2014;CO&#x2014;; &#x2014;COO&#x2014;, &#x2014;NH&#x2014;; &#x2014;S&#x2014;; &#x2014;SO&#x2014;); R, Rand Rindependently of one another are hydrogen; CCalkyl or C-C-cycloalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C-Caryl, which may be substituted by one or more G; C-Cheteroaryl, which may be substituted by one or more G, C-Calkenyl, C-Calkynyl, C-Caralkyl, or COOR; COR; CONRR; SOR; SOR; PO(R); PO(R); organosilanyl; organosiloxanyl; or a sugar residue linked directly in an &#x3b1;- or &#x3b2;-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH)&#x2014;(X)&#x2014;*, wherein n=1-10 and X&#x2550;&#x2014;C(&#x2550;O)&#x2014;; &#x2014;O&#x2014;CO&#x2014;*); Rand Rindependently from each other are hydrogen; CCalkyl or C-C-cycloalkyl which may be substituted by one or more E and/or interrupted by one or more D; C-Caryl, which may be substituted by one or more G; C-Cheteroaryl, which may be substituted by one or more G; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an &#x3b1;- or &#x3b2;-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH)&#x2014;*, wherein n=1-10); or Rand Rtogether form a five or six membered ring, Ris hydrogen; or C-Calkyl; n, n, nand nindependently from each other are a number from 1 to 5; n, nand nindependently from each other are a 0; or 1; D is &#x2014;CO&#x2014;; &#x2014;COO&#x2014;; &#x2014;S&#x2014;; &#x2014;SO&#x2014;; &#x2014;SO2-; &#x2014;O&#x2014;; &#x2014;NR&#x2014;; &#x2014;SRR&#x2014;; &#x2014;POR&#x2014;; &#x2014;CR&#x2550;CR&#x2014;; or &#x2014;C&#x2261;C&#x2014;; and E is &#x2014;OR; &#x2014;SR; &#x2014;NRR; &#x2014;NRCOR; &#x2014;COR; &#x2014;COOR; &#x2014;CONRR; &#x2014;CN; halogen; Or SOR; SOR; PO(R); PO(R); organosilanyl; organosiloxanyl; or a sugar residue linked directly in an &#x3b1;- or &#x3b2;-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH)n-(X)&#x2014;*, wherein n=1-10 and X1=&#x2014;O&#x2014;; &#x2014;C(&#x2550;O)&#x2014;; &#x2014;O&#x2014;CO&#x2014;; &#x2014;COO&#x2014;; &#x2014;NH&#x2014;; &#x2014;S&#x2014;; &#x2014;SO&#x2014;); G is E; C-Calkyl, which is optionally interrupted by D; C-Cperfluoroalkyl; C-Calkoxy, which is optionally substituted by E and/or interrupted by D; wherein R, R, Rand Rindependently of each other are hydrogen; C-Caryl which is optionally substituted by OH, C-Calkyl or C-Calkoxy; C-Calkyl, which is optionally interrupted by &#x2014;O&#x2014;; or Ri4 and Ri5 together form a five or six membered ring, Ri6 is hydrogen; C6-Ci8aryl which is optionally substituted by OH, C-Calkyl or d-Calkoxy; C-Calkyl which is optionally interrupted by &#x2014;O&#x2014;; Ris H; C-Caryl which is optionally substituted by OH, C-Calkyl or C-Calkoxy; or d-Calkyl which is optionally interrupted by &#x2014;O&#x2014;; Ris hydrogen; C-Caryl, which is optionally substituted by OH, C-Calkyl or d-Calkoxy; C-Calkyl, which is optionally interrupted by &#x2014;O&#x2014;; Rand Rindependently of each other are hydrogen; C-Calkyl; C-Caryl which is optionally substituted by C-Calkyl; and Ris C-Calkyl; or C-Caryl, which is substituted by C-Calkyl; * means, that this radical is directed to the benzotropolone moiety; for the protection of human and animal hair and skin against UV radiation. 

Use of benzotropolone derivatives as UV absorbers and antioxidants and their use in sunscreens and/or cosmetic compositions

Disclosed is the use of benzotropolone derivatives of formula whereinR, Rand Rindependently from each other are hydrogen; C-Calkyl; or COR;Ris hydrogen; or COORRis hydrogen; or C-Calkyl;Ris hydrogen; hydroxy; C-C-alkoxy; or &#x2014;O&#x2014;(CO)&#x2014;R;Ris hydrogen; C-Calkyl; or COR; orRand Rtogether may form a five or six membered ring; orRand Rtogether form a five or six membered ring; andR, R, Rindependently of each other are C-Calkyl;for protecting body-care and household products from photolytic and oxidative degradation.

Stabilization of household, body-care and food products by using benzotropolone containing plant extracts and/or related benzotropolone derivatives

The present invention provides salts of a cation and an anion, wherein the cation comprises  

Colored charged silsesquioxanes

Disclosed is the use of benzotropolone derivatives of formula (1), wherein R, Rand Rindependently from each other are hydrogen; C-Calkyl; or COR; Ris hydrogen; or COORRis hydrogen; or C-Calkyl; Ris hydrogen; hydroxy; C-C-alkoxy; or -0-(CO)&#x2014;R; Ris hydrogen; C-Calkyl; or COR; or Rand Rtogether may form a five or six membered ring; or Rand Rtogether form a five or six membered ring; and R, R, Rindependently of each other are C-Calkyl; for protecting body-care and household products from photolytic and oxidative degradation. 

The present invention relates to the preparation and use of (colored) organic particles carrying electric charge as electrophoretic (image) displaying particles, to electrophoretic dispersions comprising the organic particles carrying electric charge, electrophoretic (image) devices (especially displays) comprising the colored organic particles carrying electric charge, to the novel functionalized particles, and to their use. The particles are obtainable according to a method represented by the reaction scheme as given in FIG.

Coloured organic electrophoretic particles

The present invention discloses the use of functionalized particles as electrophoretic displaying particles, wherein the functionalized particles are SiO, AlOor mixed SiOand AlOparticles comprising, covalently bound to an oxygen atom on the surface, a radical of formula (1), wherein Rand Rare independently of each other hydrogen, particle surface-O&#x2014;, or a substituent, n is 1, 2, 3, 4, 5, 6, 7 or 8, B is the direct bond or a bridge member, and D is the residue of an organic chromophore. 

Coloured particles for electrophoretic displays

The present invention relates to derivatives of the 1H-pyrano[4,3-b]benzofuran-1-one structure and their nitrogen analogues which possess powerful antioxidant properties combined with a highly effective UV absorbing functionality in one molecule. These compounds are especially useful in cosmetical and dermatological formulations.

Coumestan-like antioxidants and UV absorbants

The present invention relates to polymerizable N-substituted acrylamide phosphorus-containing monomers, organic polymers formed from the same. Incorporation of said monomers into adhesives, pigment dispersants, coatings or films for polar surfaces or particles gives improved adhesive, anti-corrosive, and flame retardant properties.

Adhesive, coating or film composition applied to a surface

The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or &#x2014;N(CH)OCH, Ris a hydroxy-protecting group and Ris a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.

Process for the preparation of intermediates useful in the synthesis of statin derivatives

The invention relates tp dye-functionalized silsesquioxane clusters, a process for their manufacture and their use as colorants, wherein the compounds (functionalized clusters or nano-particles) are characterized by the general formula (I) wherein CAGE is a moiety of the formula (IA) D is a chromophoric moiety, and the other symbols have the meanings as defined in the specification, or salts thereof. 

Coloured silsesquioxanes

Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino-3.5-dihydroxyhepanoic acid derivatives and intermediates thereof

The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Rand Rare each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Ris a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Rand Rare each independently of the other hydrogen or a hydroxy-protecting group, and Ris a carboxy-protective group. 

Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives

The present invention relates to an improved process for the preparation of phenolic carboxylic acid derivatives catalysed by biocatalytic esterification, transesterification or amidation of a corresponding lower alkyl ester. Biocatalysis is performed in the presence of suitable enzymes, e.g. hydrolases, especially esterases, amidases, lipases and proteases.

Process for the preparation of phenolic carboxylic acid derivatives by enzymatic catalysis

Synthesis methods for the preparation of intermediates which are suitable for the preparation of statin derivatives, and especially to synthesis methods for the intermediate of formula (VI) wherein R' and R&#x2032; are each independently of the other hydrogen or hydroxy-protecting group, or together are a bridging hydroxy-protecting group; and Ris a carboxy-protecting group. 

Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation

The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH)OCH, Ris a hydroxy-protecting group, and Ris a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation. 

Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof

Growing community of inventors

Rheinfelden-Herten, Germany

Reinhold Öhrlein