Roche Diagnostics Operations, Inc.

Roche Diabetes Care, Inc.

Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Reinhold Mischler

Arnulf Staib

Martin Hajnsek

Harvey Buck

Ewald Rieger

Ortrud Quarder

Walter Jernigan

Juergen Backhaus

Ulrike Kamecke

Ralph Gillen

Dirk Boecker

Herbert Harttig

Joachim Hoenes

Thomas Meier

Frederic Wehowski

Gerhard Werner

Alexander Steck

Kirill Sliozberg

Daniel Kammerer

Gernot Hochmuth

Angelika Fuerst

Christian Hoertz

Harald Peschel

Peng Zou

The present invention relates to an enzymatic electrode comprising a conductive surface and wherein a conjugate comprising at least one enzyme molecule is covalently bound to the conductive surface. The electrode is suitable for continuous analyte monitoring, particularly for continuous glucose monitoring (CGM) with glucose oxidase (GOD) as enzyme molecule. Further, the invention relates to an electrochemical sensor for measuring the concentration of an analyte, e.g. glucose under in vivo conditions comprising the enzymatic electrode.

Continuous analyte monitoring electrode with crosslinked enzyme

Electrode systems are disclosed for measuring the concentration of an analyte under in-vivo conditions, where such systems include a counter electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.

Electrode system for measuring an analyte concentration under in-vivo conditions

An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.

Amperometric sensor and method for its manufacturing

An electrode system for measuring the concentration of an analyte under in-vivo conditions comprises a counter-electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.

The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.

Continuous monitor sensor with covalently bound enzyme

A measuring system for determining blood glucose includes a photometric measuring unit with a light source and a detector, and an analytical test element, to which a body fluid sample can be applied, and which can be placed in a beam path between the light source and the detector for optical detection of an analyte. For an improved multi-wavelength measurement, it is proposed that the light source includes a first emitter that can be actuated in a first wavelength range to emit pulsating alternating light and a second emitter that can be excited in a second wavelength range to emit fluorescent light.

Measuring system and measuring method, in particular for determining blood glucose

A sensor is described for optically determining the concentration of an analyte in a body fluid. This sensor comprises a needle arrangement which has at least one hollow needle having a hollow space extending from the distal end to the proximal end, the distal end of which is suitable for lancing. The proximal end of the needle opens into a chamber in which liquid that enters through the distal end of the needle can be collected. A window which is at least partially permeable to infrared radiation is in direct contact with the chamber.

Microneedle arrays with ATR sensor

Sample carrier for IR spectroscopy which has a sample application zone as well as at least one groove-shaped channel into which liquid is drawn from the sample application zone as a result of capillary forces. A method for IR spectroscopy using a sample carrier according to the invention and a system for IR spectroscopy using the sample carrier according to the invention.

Sample carrier for the IR spectroscopy of sample liquids

A method and apparatus for the quantitative analysis of sample liquids. A sample is dried and irradiated with visible and/or infrared light. Light that is diffusely or specularly reflected from the sample and sample carrier is detected. and analysed.

Apparatus for the quantitative analysis of sample liquid

The invention concerns a method for the quantitative analysis of sample liquids. A sample is dried and irradiated with visible and/or infrared light. Light that is diffusely or specularly reflected from the sample and sample carrier is detected and analysed. Furthermore the invention concerns a system for carrying out the method according to the invention and a sample carrier having a diffusely or specularly reflecting surface.

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Ludwigshafen, Germany

Reinhold Mischler