Inhale Therapeutic Systems, Inc.

Laboratori Guidotti

Laboratorios Menarini S.a.

Actipac Biosystems Gmbh

Menarini International Operations Luxembourg S.a.

Berlin-chemie Ag

Reinhard Schmitz

Johannes Wilhelm Tack

Celal Albayrak

Georg R&ouml;ssling

Maria Altamura

Claudia Lewerenz

Tobias Kohl

Jens Flemming

Marc Wihsmann

Stefano Manzini

Karsten Gröger

A pharmaceutical composition as a solid oral dosage form is described, comprising:

Pharmaceutical compositions containing dexketoprofen and tramadol

Oral liquid pharmaceutical compositions containing as active ingredient Nepadutant, PGS as solubilizer and optionally a chelating agent. Such compositions are found to be very stable and suitable for paediatric use in the treatment of gastro-intestinal diseases.

Pediatric oral liquid compositions containing nepadutant

The invention relates to a process for the production of morphologically uniform microcapsules that contain peptides, proteins or other water-soluble biologically active substances as active ingredients as well as microcapsules that are produced according to this process with a degree of concentration of between 3 to 30% by weight and a diameter &lE;8 &mgr;m. According to the invention, biodegradable polymers are dissolved in a halogen-free solvent or solvent mixture, and the buffered active ingredient solution, which has a pH of between 6.0 to 8.0, is dispersed into this solution. Then, an aqueous solution that contains a surfactant (W/O/W-emulsion) is added to this W/O-emulsion, and the solvent is removed. The microcapsules that are produced with this process do not show any tendency toward agglomeration. The encapsulation efficiency of the process is approximately 90 to 95%.

Process for the production of morphologically uniform microcapsules and microcapsules that are produced according to this process

Method of producing morphologically uniform microcapsules and microcapsules produced by this method

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Berlin, Germany

Reinhard Schmitz