Asta Pharma Aktiengesellschaft

Asta Medica, Aktiengesellschaft

Reinhard Muckenschnabel

Helmut Hettche

Gerhard Scheffler

Ilona Fleischhauer

Wolfgang Morick

Jurgen Engel

Salts of azelastine with acetic acid, gluconic acid, lactic acid or malic acid.

Salts of azelastine having improved solubility effective at treating

The present invention relates to salts of azelastine having improved solubility in water. The salts of the present invention are prepared by reacting azelastine with acetic acid, gluconic acid, lactic acid, or malic acid. The azelastine salts are effective in providing a cytoprotective effect.

Salts of azelastine having improved solubility useful at providing a

The present invention relates to salts of azelastine having improved solubility in water. The salts of the present invention are prepared by reacting azelastine with acetic acid, gluconic acid, lactic acid or malic acid. A pharmaceutical composition may be prepared containing an azelastine salt and a pharmaceutically-acceptable carrier or diluent therefor. The pharmaceutical composition is useful in the treatment of allergies, asthma, inflammatory and psoriasis disorders and provides a cytoprotective effect.

Salts of azelastine having improved solubility

Aerosol compressed-gas packages for the administration of biologically active substances with novel suspension stabilizers and propellants which are not harmful to ozone.

Compressed-gas packages using polyoxyethylene glyceryl fatty-acid esters

Aerosol compressed gas packages containing a member of the group consisting of polyoxyethylene-25-glyceryl trioleate, polyoxyethylene-30-glyceryl monooleate and polyoxyethylene-20-glyceryl monooleate as suspension stabilizer and/or valve lubricant. These materials are especially useful when the package contains TG 227 or TG 134a as the propellant.

Growing community of inventors

Frankfurt-am-Main, Germany

Reinhard Muckenschnabel