Ciba-Geigy Corporation

Ucp Gen-Pharma Ag

Reinhard Maschler

Markus G Grutter

Verena Steiner

Fritz Raschdorf

Novel polypeptides, designated hirullins, have a strong antithrombic activity and can therefore be used for the therapy and prophylaxis of thromboses. Said compounds are isolated from the leech Hirudinaria manillensis or are produced by conventional peptide synthesis or by recombinant DNA techniques. DNA sequences encoding hirullins P6 and P18 are supplied, hybrid vectors and transformed microorganisms for recombinant hirullin production are supplied.

DNA vector and recombinant host cell for production of hirullin P6 and

Novel polypeptides, designated hirullins, have a strong antithrombic activity and can therefore be used for the therapy and prophylaxis of thromboses. Said compounds are isolated from the leech Hirudinaria manillensis or are produced by conventional peptide synthesis or by recombinant DNA techniques.

Growing community of inventors

Oldenburg, Germany

Reinhard Maschler