Merck Patent Gesellschaft MIT Beschrankter Haftung

Reinhard Lissner

Dieter Orth

Manfred Baumgarth

Hans-Eckart Radunz

Jurgen Maisenbacher

Erich Schacht

Joachim Gante

Werner Mehrhof

Filippus J Zeelen

Hans-Joachim Enenkel

Rochus Jonas

Hans-Adolf Kurmeier

Guido Melzer

Zdenek Simane

Herbert Nowak

Hans Dahm

Gotz Leopold

Compounds of the formula ##STR1## wherein R.sup.1 is 4-biphenylyl, 4-phenoxyphenyl or 4-biphenylyl or 4-phenoxyphenyl substituted in the 4'-position by F, Cl, Br or I; R.sup.2 is H, C.sub.1-4 -alkyl, hydroxy-C.sub.1-4 -alkyl or pyridyl; R.sup.3 and R.sup.6 are each H or alkyl of 1-4 carbon atoms, or together are--(CH.sub.2).sub.4 --; and R.sup.4 and R.sup.5 are each H or together are a C--C bond; at least one of the radicals R.sup.2, R.sup.3 and R.sup.6 being other than hydrogen, possess valuable pharmacological properties, e.g., lower lipid levels and are anti-thrombotic.

Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process

Compounds of formula ##STR1## their mirror images and racemic mixtures, and the physiologically acceptable salts thereof,

New prostaglandin-like diketals

Compounds of the Formula ##STR1## and the physiologically acceptable salts thereof, wherein R.sup.1 and R.sub.2 each is hydrogen or benzyl; R.sup.3 is alkyl of 5-10 C-atoms or 2-hydroxyalkyl of 5-10 C-atoms; R.sup.4 is hydrogen, methyl or ethyl; R.sup.5 is alkyl of 5-10 C-atoms or --C.sub.n H.sub.2n COOR.sup.6 ; R.sup.6 is hydrogen or alkyl of 1-4 C-atoms; and n is 0, 4, 5 or 6 are effective for inhibiting adhesion and/or agglomeration of thrombocytes.

Cyclopentan-1-amines

New quinolone derivatives of the Formula I ##STR1## wherein R.sup.1 and R.sup.2 are each H, F, Cl, Br, CF.sub.3 or CH.sub.3 O or a physiologically acceptable acid addition salt thereof possess pharmacological properties including thrombocyte aggregation inhibiting action.

Quinolone derivatives

1,4-Oxathianes of the formula ##STR1## and the physiologically-acceptable salts thereof wherein R.sup.1 is H or alkyl with 1-4 C-atoms; R.sup.2 is H or alkyl with 1-4 C-atoms; R.sup.3 is H, alkyl with 1-8 C-atoms, phenyl or phenyl substituted by F, Cl, Br, OH, OCH.sub.3, CF.sub.3 or NO.sub.2 ; R.sup.4 is H or CH.sub.3 ; B is a single bond, --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.sub.2 O--; and a wavy line (  ) indicates that these bonds can be in the .alpha.- or .beta.- positions possess thrombocyte inhibition properties.

1,4-Oxathianes

Prostenoic acid derivatives of the general formula ##STR1## wherein R.sup.1 is H or alkyl of 1-4 carbon atoms;

Prostenoic acid derivatives

Prostenoic acid derivatives of the general formula ##STR1## wherein R.sup.1 is H or alkyl or 1-4 carbon atoms;

2-(4,5-BIS-P-CHLOROPHENYLOXAZOL-2-YL-MERCAPTO)-PROPIONIC ACID AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS IS USEFUL FOR SUPPRESSING AGGREGATION OF THROMBOCYTES, PARTICULARLY WHEN ADMINISTERED IN COMBINATION WITH ASPIRIN.

Suppression of thrombocyte aggregation

Biphenylyl ethers of the formula ##STR1## and their physiologically acceptable acid addition salts exhibit pharmaceutically useful serum cholesterol and triglyceride lowering, fibrinolytic, thrombocyte aggregation inhibition, .beta.-receptor blocking and neuroleptic effects.

Growing community of inventors

Darmstadt, Germany

Reinhard Lissner