Riedel-De Haen Aktiengesellschaft

Reinhard Knieps

Gunter Bartels

Andreas Winterfeldt

Kurt Eiglmeier

According to the process according to the invention, substantially fluorinated alkyl bromides, preferably perfluoroalkyl bromides, are prepared by reaction of substantially fluorinated alkyl iodides, with phase transfer catalysts in the bromide form.

Process for the preparation of substantially fluorinated alkyl bromides

Substituted bromofluorobenzene, wherein the fluorine is in para-position and the bromine in meta-position to another substituent, is prepared by direct bromination of the corresponding fluorobenzene derivative. Bromination is advantageously carried out in the presence of a catalyst, preferably a metal or metal salt. The elementary bromine is used in an amount of 0.9 to 1.3 mols per mol of fluorobenzene derivative and the reaction temperature is between 20.degree. and 200.degree. C. The bromofluorobenzene derivatives are suitable for the synthesis of medicaments and plant protective agents.

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Hanover, Germany

Reinhard Knieps