Hoffmann-la Roche Inc.

Cytiva Sweden Ab

Reinhard Braaz

Anna Grönberg

Magnus Asplund

Anders Nilsson

Johan Avallin

Josef Vinnemeier

Henrik Ingvarsson

Benedikt Scheidecker

Agathe Justine Ballin

Linda Persson

The invention discloses a method for sanitization of a bioprocess chromatography column, comprising the steps of: a) providing a bioprocess chromatography column with a packed bed of separation resin particles and a movable adapter, b) with the adapter in contact with the packed bed, conveying a sanitization fluid through the packed bed to a column outlet; c) raising the adapter to provide a gap between the packed bed and the adapter, d) lowering the adapter to close the gap; and e) conveying an equilibration liquid through the packed bed to a column outlet.

Method for sanitization of a chromatography column

Methods and systems for online sampling an aliquot from a mobile phase comprising an analyte for producing a pharmaceutical or chemical product, wherein the apparatus comprises an analytical device and a tube between an inlet and an outlet, wherein the outlet is in fluid communication with the analytical device, the method comprising: providing a sample device comprising a needle with a needle tip, a septum pierceable by the needle and a pump, wherein the needle is moveable between an extended position in which the septum is pierced by the needle, and a retracted position, in which the septum is not pierced, disposing the sample device at the curved portion of the tube, moving the needle to the extended position such that the needle tip faces the flow direction, and drawing out an aliquot out of the mobile phase.

Method for online sampling an aliquot from a mobile phase comprising an analyte of an apparatus for producing a pharmaceutical or chemical product

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Penzberg, Germany

Reinhard Braaz