Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Reiner Scherer

Gerhard Ruhenstroth-Bauer

The increase in concentration of one or several plasma-proteins in the blood is specific for various pathological processes, especially inflammations. A medicament which in a typical way, exactly contains increasingly available plasma-proteins for a pathological process, attenuates the progress of the pathological process, as by this means, the defence system of the body itself is strengthened, which reacts in a specific way on such pathological processes, with the increased formation of one or several plasma-proteins specific for this. This effect is especially demonstrated in regard to Fibrinogen. It demonstrates further that the effect of the Fibrinogen is thereupon to be traced back in that, in regard to reaction with Thrombin at the point of the inflammation, the fibrinopeptides A and B are formed.

Medicaments for the suppression of pathological processes

A method for simultaneous qualitative and quantitative analysis of antigens r antigen-effective substances in a sample provides placing the sample in a carrier medium through which it migrates toward a plurality of physically separate carrier strips. The medium on each strip contains a quantity of a specific ingredient, for example an antibody, which is expected to undergo a specific immunoreaction with one of the constituents in the sample, thereby producing a visible precipitate. The dimensions of the final precipitate then permit a direct measurement of the identified substance. A known concentration of a calibrating substance may be added to the sample to provide for calibration precipitates in the various strips. The apparatus for practicing the method includes a base plate on which the neutral, antibody-free carrier medium as well as the various strips containing media with antibodies or other immunoreactive ingredients are located. An electric field may be applied to aid in the migration of the sample in the medium.

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Munich, Germany

Reiner Scherer