Bayer Aktiengesellschaft

Kali-Chemie Pharma Gmbh

Miles Inc.

Reiner Muller-Peddinghaus

Siegfried Raddatz

Romanis Fruchtmann

Christian Kohlsdorfer

Pia Theisen-Popp

Klaus-Helmut Mohrs

Michael Matzke

Armin Hatzelmann

Klaus Mohrs

Ulf Preuschoff

Ivan Ban

Michael Wurl

Rainer Walenta

Elisabeth Perzborn

Burkhard Fugmann

Cheryl L Nickerson-Nutter

David D Wood

Paul J Marshall

Pia Theisen

The novel quinolin-2-yl-methoxybenzylhydroxyureas can be prepared by reaction of appropriate ketones with hydroxylamine and reduction of the ketoximes and subsequent reaction with isocyanates. The new substances can be employed as active substances in medicaments.

Quinolin-2-yl-methoxybenzylhydroxyureas

Described are methods for ameliorating symptoms associated with inflammatory bowel disease such as ulcerative colitis and Crohn's disease (regional enteritis) with four specific quinoline leukotriene synthesis inhibitors.

Methods for treating inflammatory bowel disease with leukotriene

A (quinolin-2-yl-methoxy) phenylacyl-sulphonamide or -cyanamide of the formula ##STR1## and physiologically acceptable salts thereof. The (quinolin-2-yl-methoxy)phenylacylsulphonamide or -cyanamide is useful as an active compound in medicaments, particularly as a lipoxygenase inhibitor.

Substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphon-amides and

Quinolylmethoxyphenyl-acetamides of the formula: ##STR1## in which A, B, D, E, G, L and M are hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy or optionally substituted aryl;

Quinolylmethoxyphenyl-acetamides

The title compounds are prepared either by reacting the corresponding halogenomethylquinolines with substituted phenols, optionally subsequently alkylating these or hydrolysing esters to acids, or by reacting phenyl-substituted quinolinecarboxylic acid derivatives with sulphonamides. The new phenyl-substituted quinolines are utilizable as active substances in medicaments, in particular as lipoxygenase inhibitors.

2-substituted quinolines, and their use in medicaments

Substituted mandelic acid derivatives can be prepared by reaction of glyoxylic esters with Grignard compounds. The substituted mandelic acid derivatives are suitable as active compounds in medicaments, in particular for medicaments which inhibit leukotriene synthesis.

Substituted mandelic acid derivatives and their use in medicaments

Quinolylmethoxyphenylacetic acid acylamides and ureas can be prepared either by reacting corresponding carboxylic acids with amides or reacting corresponding amides with isocyanates or ureas. The quinolylmethoxyphenylacetic acid acylamides or ureas can be used as active compounds in medicaments.

Quinolylmethoxyphenylacetic acid acylamides and ureas

Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of halogenoacetoacetic acid esters with quinolylmethoxyphenylacetic acid thioamides, which are obtainable from corresponding amides with Lawesson's reagent. The substances can be employed in medicaments as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism.

Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives

Heterocyclically substituted quinolylmethoxyphenylacetamides are prepared by amidation of corresponding carboxylic acids. The compounds can be used in medicaments, in particular those having lipoxygenase-inhibiting action.

Heterocyclically substituted quinolylmethoxy-phenylacetamides

For inhibiting lipoxygenzce, (quinolin-2-yl-methoxy) phenylacetic acid derivatives containing cyclic substituents of the formula ##STR1## in which A, Q, D, E, G, T and M are hydrogen or various radicals,

(Quinolin-2-yl-methoxy)phenylacetic acid derivatives containing cyclic

Inhibiting leucotriene synthesis in patients with novel substituted N-(quinolin-2-yl-methoxy)benzylsulphonyl-urea of the formula ##STR1## in which A, B, D, E, G, K and M each independently is H, OH, halogen, CF.sub.3, OCF.sub.3, COOH, alkyl, alkoxy, alkoxycarbonyl or aryl,

Substituted N-(quinolin-2-yl-methoxy) benzyl-sulphonylurea leukotriene

Inhibiting leucotriene synthesis in patients with novel disubstituted (quinolin-3-yl-methoxy)phenylacetic acid derivatives of the formula ##STR1## in which A, B, D, E, G, K and M each independently is H, OH, halogen, CF.sub.3, OCF.sub.3, COOH, alkyl, alkoxycarbonyl or aryl,

Leukotriene synthesis-inhibiting disubstituted (quinolin-2-yl-methoxy)

Substituted (quinolin-2-ylmethoxy)phenyl-thio-ureas of the formula ##STR1## in which A, B, D, E, G, K and M

Substituted (quinolin-2-yl-methoxy)phenylthioureas

A quinolin-2-yl-methoxy)phenylacyl-sulphonamide or -cyanamide of the formula ##STR1## in which A, B, D, E, F and G are identical or different and

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Bergisch-Gladbach, Germany

Reiner Muller-Peddinghaus